Detailed information of TA system TA046652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 966886..968123
• Replicon: chromosome
• Accession: NZ_CP007573
• Organism: Streptococcus anginosus strain SA1

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A1X1G346
• Locus tag: DK43_RS04680
• Protein ID: WP_041331778.1
• Coordinates: 967362..968123 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: DK43_RS04675
• Protein ID: WP_000579610.1
• Coordinates: 966886..967362 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK43_RS04635	963143..963427	+	285	WP_000969643.1	hypothetical protein	-
DK43_RS04640	963441..963737	+	297	WP_020903367.1	hypothetical protein	-
DK43_RS04645	963751..963948	-	198	WP_002933288.1	hypothetical protein	-
DK43_RS04650	964108..964749	+	642	WP_037612723.1	hypothetical protein	-
DK43_RS04655	964759..965844	+	1086	WP_037612722.1	toprim domain-containing protein	-
DK43_RS04660	965895..966128	+	234	WP_037612720.1	hypothetical protein	-
DK43_RS04665	966125..966508	+	384	WP_002933294.1	hypothetical protein	-
DK43_RS04670	966546..966818	+	273	WP_037612719.1	hypothetical protein	-
DK43_RS04675	966886..967362	+	477	WP_000579610.1	helix-turn-helix domain-containing protein	Antitoxin
DK43_RS04680	967362..968123	+	762	WP_041331778.1	zeta toxin family protein	Toxin
DK43_RS10100	968151..970649	+	2499	Protein_925	recombinase RecF	-
DK43_RS04695	971569..971925	+	357	WP_001115082.1	hypothetical protein	-
DK43_RS04700	971930..972295	+	366	WP_037612713.1	MobC family plasmid mobilization relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29030.93 Da
• Isoelectric Point: 6.4173

>T46652 WP_041331778.1 NZ_CP007573:967362-968123 [Streptococcus anginosus]
MDIQDYTDSAFKHALERNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKETAQHLKSKGYEVQLAIIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEEIAIFERIQIYQRDRSCVYDSKENTAPAADILQELLFGEWSQVEKEML
KVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T46652 NZ_CP007573:967362-968123 [Streptococcus anginosus]
ATGGATATCCAAGATTATACTGATAGTGCATTTAAACATGCTTTAGAGCGAAACCTTCGCTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCTGGTAAGACTACAATTCATCGAATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCACCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCGGGAAAAATGGTAGAGTCTCTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAATTGATGTTCCAAAGGAAACAGCACAACACTTGAAAAGTA
AGGGATATGAAGTACAATTAGCCATAATCGCAACAAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
TTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAAATAGCTATCTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAGCTCCAGCAGCAGATATTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAAGAGATGTTG
AAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18217.63 Da
• Isoelectric Point: 4.3457

>AT46652 WP_000579610.1 NZ_CP007573:966886-967362 [Streptococcus anginosus]
MIGKNIKSLRKTHDLTQPEFAQIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT46652 NZ_CP007573:966886-967362 [Streptococcus anginosus]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACACGACTTAACACAACCCGAATTTGCCCAAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAGCTAATAGACATCATTTGTCAAAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGACAAAATGCTTAATCCTGTTGAAGATTATGAACTGACTTTAAAAATTGAA
ATAGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTTTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTTGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAGCGCATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Structures

Toxin

• AlphaFold DB: A0A1X1G346