Detailed information of TA system TA046651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 115773..116380
• Replicon: chromosome
• Accession: NZ_CP007573
• Organism: Streptococcus anginosus strain SA1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: R4SB26
• Locus tag: DK43_RS00565
• Protein ID: WP_003027804.1
• Coordinates: 116189..116380 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: R4SEZ1
• Locus tag: DK43_RS00560
• Protein ID: WP_003027805.1
• Coordinates: 115773..116153 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK43_RS00540	110878..111318	+	441	WP_003027809.1	arginine repressor	-
DK43_RS00545	111576..114137	+	2562	WP_022525220.1	DNA mismatch repair protein MutS	-
DK43_RS00550	114326..114784	-	459	WP_003027807.1	DUF3021 domain-containing protein	-
DK43_RS00555	114781..115221	-	441	WP_022525219.1	LytTR family transcriptional regulator	-
DK43_RS00560	115773..116153	-	381	WP_003027805.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DK43_RS00565	116189..116380	-	192	WP_003027804.1	type II toxin-antitoxin system HicA family toxin	Toxin
DK43_RS00570	116899..117339	-	441	WP_022525218.1	hypothetical protein	-
DK43_RS00575	117588..118439	-	852	WP_003027802.1	ATP-binding protein	-
DK43_RS00580	118454..119245	-	792	WP_003027801.1	phage replisome organizer N-terminal domain-containing protein	-
DK43_RS00585	119254..119523	-	270	WP_003027800.1	hypothetical protein	-
DK43_RS00590	119525..119860	-	336	WP_003027798.1	hypothetical protein	-
DK43_RS00595	119857..120093	-	237	WP_003027797.1	hypothetical protein	-
DK43_RS10385	120083..120259	-	177	WP_003027795.1	hypothetical protein	-
DK43_RS00600	120256..120534	-	279	WP_003027794.1	hypothetical protein	-
DK43_RS10390	120878..121045	-	168	WP_003027793.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7163.29 Da
• Isoelectric Point: 9.7310

>T46651 WP_003027804.1 NZ_CP007573:c116380-116189 [Streptococcus anginosus]
MPLTGKEMAKLAEKNGWVEIRQNGSHHHFKHKDFDYIVTIPIHGNQDLGKGLESKILKDLGLK

Nucleotide

• Length: 192 bp

>T46651 NZ_CP007573:c116380-116189 [Streptococcus anginosus]
ATGCCACTTACAGGAAAAGAAATGGCAAAGCTAGCCGAGAAAAATGGTTGGGTAGAAATCCGACAGAACGGCAGTCATCA
CCATTTCAAACATAAAGATTTTGATTATATAGTGACTATCCCAATTCATGGAAACCAGGATTTAGGGAAAGGGCTAGAAA
GCAAAATCCTGAAAGATTTGGGGCTGAAATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14136.16 Da
• Isoelectric Point: 4.6265

>AT46651 WP_003027805.1 NZ_CP007573:c116153-115773 [Streptococcus anginosus]
MLKSYPAIFHKEEDGSYWVEFPEFGGGTQGANVEEALKNAREMLESVLAAYIDEGLDMPKPSDIMTLTVKGGFVSMIQAD
PTPFIRNNKAIRKNVTVPEWLVRLADREKVNYSEVLTQALETKLQA

Nucleotide

• Length: 381 bp

>AT46651 NZ_CP007573:c116153-115773 [Streptococcus anginosus]
ATGTTAAAATCATATCCAGCAATTTTTCATAAAGAGGAAGACGGTTCTTATTGGGTAGAATTTCCAGAGTTCGGAGGAGG
CACACAAGGAGCAAATGTTGAAGAAGCCTTGAAAAATGCCCGTGAAATGCTTGAGAGTGTTTTAGCTGCTTACATAGACG
AAGGATTAGATATGCCAAAACCTAGTGACATCATGACTTTAACCGTTAAAGGCGGCTTTGTTAGCATGATACAAGCAGAC
CCCACCCCTTTTATTCGCAACAATAAAGCCATTAGAAAGAATGTGACTGTCCCTGAATGGTTAGTAAGATTAGCAGATCG
TGAAAAAGTAAATTATTCTGAAGTGCTAACTCAAGCCCTAGAAACAAAATTACAAGCCTAG

Structures

Toxin

• AlphaFold DB: R4SB26

Antitoxin

• AlphaFold DB: R4SEZ1