Detailed information of TA system TA046650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2168131..2168755
• Replicon: chromosome
• Accession: NZ_CP007572
• Organism: Streptococcus agalactiae strain GBS6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: DX05_RS10775
• Protein ID: WP_000253103.1
• Coordinates: 2168131..2168478 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: DX05_RS10780
• Protein ID: WP_000543070.1
• Coordinates: 2168468..2168755 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DX05_RS10755	2163847..2164203	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
DX05_RS10760	2164270..2166588	-	2319	WP_000883426.1	YhgE/Pip domain-containing protein	-
DX05_RS10765	2166727..2167266	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
DX05_RS10770	2167352..2167648	-	297	WP_001052251.1	DUF4298 domain-containing protein	-
DX05_RS10775	2168131..2168478	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DX05_RS10780	2168468..2168755	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DX05_RS10785	2168824..2169201	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
DX05_RS11960	2169176..2169328	-	153	Protein_2061	DUF1492 domain-containing protein	-
DX05_RS10790	2169335..2169823	-	489	WP_000891152.1	hypothetical protein	-
DX05_RS10795	2169896..2170453	-	558	WP_001258765.1	hypothetical protein	-
DX05_RS11740	2170611..2170784	-	174	WP_000694573.1	hypothetical protein	-
DX05_RS10805	2170781..2171038	-	258	WP_001069293.1	hypothetical protein	-
DX05_RS10810	2171331..2172725	-	1395	WP_000656430.1	hypothetical protein	-
DX05_RS10815	2172737..2173594	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2167352..2184620	17268

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T46650 WP_000253103.1 NZ_CP007572:c2168478-2168131 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T46650 NZ_CP007572:c2168478-2168131 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT46650 WP_000543070.1 NZ_CP007572:c2168755-2168468 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT46650 NZ_CP007572:c2168755-2168468 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5