Detailed information of TA system TA046649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 270132..270744
• Replicon: chromosome
• Accession: NZ_CP007572
• Organism: Streptococcus agalactiae strain GBS6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: DX05_RS01555
• Protein ID: WP_000384859.1
• Coordinates: 270132..270467 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: DX05_RS01560
• Protein ID: WP_000259017.1
• Coordinates: 270457..270744 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DX05_RS01525	265330..265971	+	642	WP_000591144.1	hypothetical protein	-
DX05_RS01535	266271..267146	+	876	WP_000421240.1	hypothetical protein	-
DX05_RS01540	267182..267616	+	435	WP_001220479.1	hypothetical protein	-
DX05_RS01545	267933..269189	+	1257	WP_000122836.1	plasmid recombination protein	-
DX05_RS01550	269357..269827	+	471	WP_000130119.1	hypothetical protein	-
DX05_RS01555	270132..270467	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DX05_RS01560	270457..270744	-	288	WP_000259017.1	hypothetical protein	Antitoxin
DX05_RS01565	271251..271541	+	291	WP_000078284.1	WXG100 family type VII secretion target	-
DX05_RS01570	271643..272050	+	408	WP_000749960.1	hypothetical protein	-
DX05_RS01575	272136..272543	+	408	WP_000749954.1	hypothetical protein	-
DX05_RS01580	273077..273757	+	681	WP_025194578.1	hypothetical protein	-
DX05_RS01585	273742..274128	+	387	WP_000259071.1	hypothetical protein	-
DX05_RS01590	274162..274443	+	282	WP_000052403.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T46649 WP_000384859.1 NZ_CP007572:c270467-270132 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T46649 NZ_CP007572:c270467-270132 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT46649 WP_000259017.1 NZ_CP007572:c270744-270457 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT46649 NZ_CP007572:c270744-270457 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6