Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2181673..2182297 Replicon chromosome
Accession NZ_CP007570
Organism Streptococcus agalactiae strain GBS1-NY

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag DK41_RS10800 Protein ID WP_000253103.1
Coordinates 2181673..2182020 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag DK41_RS10805 Protein ID WP_000543070.1
Coordinates 2182010..2182297 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK41_RS10780 2177389..2177745 - 357 WP_000105934.1 DUF1304 domain-containing protein -
DK41_RS10785 2177812..2180130 - 2319 WP_000883426.1 YhgE/Pip domain-containing protein -
DK41_RS10790 2180269..2180808 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
DK41_RS10795 2180894..2181190 - 297 WP_001052251.1 DUF4298 domain-containing protein -
DK41_RS10800 2181673..2182020 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK41_RS10805 2182010..2182297 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DK41_RS10810 2182366..2182743 - 378 WP_000038826.1 DUF1492 domain-containing protein -
DK41_RS11910 2182718..2182870 - 153 Protein_2054 DUF1492 domain-containing protein -
DK41_RS10815 2182877..2183365 - 489 WP_000891152.1 hypothetical protein -
DK41_RS10820 2183438..2183995 - 558 WP_001258765.1 hypothetical protein -
DK41_RS11710 2184153..2184326 - 174 WP_000694573.1 hypothetical protein -
DK41_RS10830 2184323..2184580 - 258 WP_001069293.1 hypothetical protein -
DK41_RS10835 2184873..2186267 - 1395 WP_000656430.1 hypothetical protein -
DK41_RS10840 2186279..2187136 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T46645 WP_000253103.1 NZ_CP007570:c2182020-2181673 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

>T46645 NZ_CP007570:c2182020-2181673 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT46645 WP_000543070.1 NZ_CP007570:c2182297-2182010 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp

>AT46645 NZ_CP007570:c2182297-2182010 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References