Detailed information of TA system TA046643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 2482864..2483432
• Replicon: chromosome
• Accession: NZ_CP007567
• Organism: Aeromonas media WS

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: B224_RS11180
• Protein ID: WP_041206022.1
• Coordinates: 2483139..2483432 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: B224_RS11175
• Protein ID: WP_041206021.1
• Coordinates: 2482864..2483151 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B224_RS23095	2478011..2478136	-	126	WP_158319065.1	hypothetical protein	-
B224_RS11140	2478166..2478996	-	831	WP_147273949.1	hypothetical protein	-
B224_RS11145	2479159..2479419	+	261	WP_005323888.1	hypothetical protein	-
B224_RS11150	2479473..2479877	-	405	WP_041206017.1	IS200/IS605-like element ISAs26 family transposase	-
B224_RS11155	2479935..2481161	+	1227	WP_041206018.1	transposase	-
B224_RS11160	2481297..2481548	+	252	WP_041206019.1	DUF4160 domain-containing protein	-
B224_RS11165	2481532..2481954	+	423	WP_041206020.1	DUF2442 domain-containing protein	-
B224_RS11170	2482349..2482531	+	183	WP_005324832.1	Rop family plasmid primer RNA-binding protein	-
B224_RS11175	2482864..2483151	+	288	WP_041206021.1	CopG family ribbon-helix-helix protein	Antitoxin
B224_RS11180	2483139..2483432	+	294	WP_041206022.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B224_RS23100	2483585..2483872	+	288	WP_147273935.1	hypothetical protein	-
B224_RS22385	2484094..2484612	+	519	WP_081805719.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
B224_RS22390	2484815..2485177	+	363	Protein_2211	replication initiation protein	-
B224_RS11190	2485351..2486619	+	1269	WP_041206016.1	IS4-like element ISAeme4 family transposase	-
B224_RS11195	2486954..2487964	+	1011	WP_158319066.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(E)	-	2436742..2502167	65425
	-	inside	IScluster/Tn	tet(E)	-	2473182..2506795	33613

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10892.68 Da
• Isoelectric Point: 10.8518

>T46643 WP_041206022.1 NZ_CP007567:2483139-2483432 [Aeromonas media WS]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALTQLGQQPAMGRPIEGLPEAFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Nucleotide

• Length: 294 bp

>T46643 NZ_CP007567:2483139-2483432 [Aeromonas media WS]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGTCCGGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGCTCGGCGCTGACCCAGCTCGGGCAACAACCCGCGATGGGTCGTCCTATTG
AAGGGCTCCCGGAGGCGTTCCGCGAGTGGGTGATCCCCTTTGGTGACAGTGGTTATCTGGCGCGTTACCGCTTAGAGGGC
GAAACCGTAGTGATCTTGGCCCTGCGTCACCAACGCGAAGCTGGATTTATTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10878.14 Da
• Isoelectric Point: 5.1800

>AT46643 WP_041206021.1 NZ_CP007567:2482864-2483151 [Aeromonas media WS]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLDEADQWLA
GWGTEIEGGAPACHK

Nucleotide

• Length: 288 bp

>AT46643 NZ_CP007567:2482864-2483151 [Aeromonas media WS]
ATGTCAGCAGCGACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGACGAGGCCGACCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA