Detailed information of TA system TA046640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1470514..1471129
• Replicon: chromosome
• Accession: NZ_CP007562
• Organism: Streptococcus pyogenes strain NGAS327

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0H3C0F8
• Locus tag: DK93_RS07235
• Protein ID: WP_009880846.1
• Coordinates: 1470794..1471129 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: DK93_RS07230
• Protein ID: WP_047236158.1
• Coordinates: 1470514..1470804 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK93_RS07205	1465694..1466677	-	984	WP_012561005.1	tagatose-bisphosphate aldolase	-
DK93_RS07210	1466681..1467610	-	930	WP_012561006.1	tagatose-6-phosphate kinase	-
DK93_RS07215	1467656..1468171	-	516	WP_012561007.1	galactose-6-phosphate isomerase subunit LacB	-
DK93_RS07220	1468206..1468634	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
DK93_RS07225	1469080..1469853	+	774	WP_009880844.1	DeoR/GlpR family DNA-binding transcription regulator	-
DK93_RS07230	1470514..1470804	+	291	WP_047236158.1	XRE family transcriptional regulator	Antitoxin
DK93_RS07235	1470794..1471129	+	336	WP_009880846.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DK93_RS08750	1471281..1471751	+	471	Protein_1360	integrase	-
DK93_RS08525	1471865..1472215	+	351	WP_111679863.1	tyrosine-type recombinase/integrase	-
DK93_RS07240	1472383..1472775	-	393	WP_002982716.1	30S ribosomal protein S9	-
DK93_RS07245	1472796..1473242	-	447	WP_002982710.1	50S ribosomal protein L13	-
DK93_RS07250	1473460..1473666	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
DK93_RS07255	1473663..1474361	-	699	WP_038431592.1	hypothetical protein	-
DK93_RS07260	1474497..1475357	-	861	WP_023611214.1	DegV family protein	-
DK93_RS07265	1475454..1475972	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13204.95 Da
• Isoelectric Point: 5.6809

>T46640 WP_009880846.1 NZ_CP007562:1470794-1471129 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T46640 NZ_CP007562:1470794-1471129 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAAGTTTTCCGAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.73 Da
• Isoelectric Point: 6.3953

>AT46640 WP_047236158.1 NZ_CP007562:1470514-1470804 [Streptococcus pyogenes]
MTTVKKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVR
QGKFYTSEEVRAELGL

Nucleotide

• Length: 291 bp

>AT46640 NZ_CP007562:1470514-1470804 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATT
AAACAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTAT
TGACGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGT
CAAGGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A0H3C0F8