Detailed information of TA system TA046639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1534911..1535523
• Replicon: chromosome
• Accession: NZ_CP007561
• Organism: Streptococcus pyogenes strain NGAS596

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DK92_RS07555
• Protein ID: WP_047235979.1
• Coordinates: 1535188..1535523 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: DK92_RS07550
• Protein ID: WP_002988079.1
• Coordinates: 1534911..1535198 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK92_RS07525	1530102..1531085	-	984	WP_002988088.1	tagatose-bisphosphate aldolase	-
DK92_RS07530	1531089..1532018	-	930	WP_002988085.1	tagatose-6-phosphate kinase	-
DK92_RS07535	1532064..1532579	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
DK92_RS07540	1532614..1533042	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
DK92_RS07545	1533488..1534261	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
DK92_RS07550	1534911..1535198	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
DK92_RS07555	1535188..1535523	+	336	WP_047235979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DK92_RS09320	1535675..1536145	+	471	Protein_1418	tyrosine-type recombinase/integrase family protein	-
DK92_RS09060	1536108..1536608	+	501	WP_111690826.1	site-specific integrase	-
DK92_RS07560	1536776..1537168	-	393	WP_002982716.1	30S ribosomal protein S9	-
DK92_RS07565	1537189..1537635	-	447	WP_002982710.1	50S ribosomal protein L13	-
DK92_RS07570	1537853..1538059	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
DK92_RS07575	1538056..1538754	-	699	WP_038431592.1	hypothetical protein	-
DK92_RS07580	1538890..1539750	-	861	WP_002982687.1	DegV family protein	-
DK92_RS07585	1539847..1540365	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13159.91 Da
• Isoelectric Point: 5.2233

>T46639 WP_047235979.1 NZ_CP007561:1535188-1535523 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFEADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T46639 NZ_CP007561:1535188-1535523 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGAGGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT46639 WP_002988079.1 NZ_CP007561:1534911-1535198 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT46639 NZ_CP007561:1534911-1535198 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGAGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94