Detailed information of TA system TA046638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1674644..1675256
• Replicon: chromosome
• Accession: NZ_CP007560
• Organism: Streptococcus pyogenes strain NGAS743

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DI45_RS08580
• Protein ID: WP_002994716.1
• Coordinates: 1674921..1675256 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: DI45_RS08575
• Protein ID: WP_002988079.1
• Coordinates: 1674644..1674931 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DI45_RS08550	1669836..1670819	-	984	WP_047235487.1	tagatose-bisphosphate aldolase	-
DI45_RS08555	1670823..1671752	-	930	WP_047235488.1	tagatose-6-phosphate kinase	-
DI45_RS08560	1671798..1672313	-	516	WP_047235489.1	galactose-6-phosphate isomerase subunit LacB	-
DI45_RS08565	1672348..1672776	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
DI45_RS08570	1673221..1673994	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
DI45_RS08575	1674644..1674931	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
DI45_RS08580	1674921..1675256	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DI45_RS10375	1675408..1675878	+	471	Protein_1630	tyrosine-type recombinase/integrase family protein	-
DI45_RS10090	1675841..1676389	+	549	WP_115224415.1	site-specific integrase	-
DI45_RS08590	1676523..1676915	-	393	WP_002982716.1	30S ribosomal protein S9	-
DI45_RS08595	1676936..1677382	-	447	WP_047235490.1	50S ribosomal protein L13	-
DI45_RS08600	1677600..1677806	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
DI45_RS08605	1677803..1678501	-	699	WP_047235491.1	hypothetical protein	-
DI45_RS08610	1678637..1679497	-	861	WP_002982687.1	DegV family protein	-
DI45_RS08615	1679594..1680112	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T46638 WP_002994716.1 NZ_CP007560:1674921-1675256 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T46638 NZ_CP007560:1674921-1675256 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT46638 WP_002988079.1 NZ_CP007560:1674644-1674931 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT46638 NZ_CP007560:1674644-1674931 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94