46625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 3072848..3073419 Replicon chromosome
Accession NZ_CP007557
Organism Citrobacter freundii CFNIH1

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag CFNIH1_RS14500 Protein ID WP_011918375.1
Coordinates 3073108..3073419 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag CFNIH1_RS14495 Protein ID WP_011787805.1
Coordinates 3072848..3073108 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFNIH1_RS14470 3068059..3068640 - 582 Protein_2845 porin -
CFNIH1_RS14475 3069138..3070628 + 1491 WP_011787801.1 SulP family inorganic anion transporter -
CFNIH1_RS14480 3070663..3071517 + 855 WP_011787802.1 universal stress protein -
CFNIH1_RS14485 3071608..3071940 + 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
CFNIH1_RS14490 3072058..3072678 - 621 WP_011787804.1 recombinase family protein -
CFNIH1_RS14495 3072848..3073108 + 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CFNIH1_RS14500 3073108..3073419 + 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFNIH1_RS14505 3073443..3076523 + 3081 WP_011787830.1 Tn3 family transposase -
CFNIH1_RS26805 3076579..3077070 - 492 Protein_2853 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T46625 WP_011918375.1 NZ_CP007557:3073108-3073419 [Citrobacter freundii CFNIH1]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T46625 NZ_CP007557:3073108-3073419 [Citrobacter freundii CFNIH1]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT46625 WP_011787805.1 NZ_CP007557:3072848-3073108 [Citrobacter freundii CFNIH1]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT46625 NZ_CP007557:3072848-3073108 [Citrobacter freundii CFNIH1]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References