Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1843240..1843759 Replicon chromosome
Accession NZ_CP007557
Organism Citrobacter freundii CFNIH1

Toxin (Protein)


Gene name relE Uniprot ID A0A2Z3WY74
Locus tag CFNIH1_RS08820 Protein ID WP_038636706.1
Coordinates 1843478..1843759 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2Z3X2E3
Locus tag CFNIH1_RS08815 Protein ID WP_038636704.1
Coordinates 1843240..1843488 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFNIH1_RS08805 1838974..1839918 + 945 WP_038642979.1 type VI secretion system baseplate subunit TssG -
CFNIH1_RS08810 1839909..1842431 + 2523 WP_038636701.1 type VI secretion system ATPase TssH -
CFNIH1_RS27945 1842457..1843092 + 636 WP_129694863.1 hypothetical protein -
CFNIH1_RS08815 1843240..1843488 + 249 WP_038636704.1 plasmid stabilization protein Antitoxin
CFNIH1_RS08820 1843478..1843759 + 282 WP_038636706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFNIH1_RS08825 1843786..1845750 + 1965 WP_038636709.1 type VI secretion system tip protein VgrG -
CFNIH1_RS08830 1845750..1846271 + 522 WP_038636711.1 toxin-antitoxin system YwqK family antitoxin -
CFNIH1_RS08835 1846293..1846757 - 465 WP_038636713.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.76 Da        Isoelectric Point: 10.4466

>T46622 WP_038636706.1 NZ_CP007557:1843478-1843759 [Citrobacter freundii CFNIH1]
MTYSLEFLDIALKEWRKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Download         Length: 282 bp

>T46622 NZ_CP007557:1843478-1843759 [Citrobacter freundii CFNIH1]
ATGACCTATAGTCTGGAGTTTTTAGATATTGCGCTCAAGGAGTGGCGCAAACTTTCACCCACATTACGCGAGCAGTTCAA
AAAGAAGCTAGCGGAACGGCTAGAGAACCCTCATGTCCCTGCCGCCCGCCTGTCTGGCAAATTACACCGTTATAAAATCA
AGCTACGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCCGTGGGCAGA
CGTGATGGCGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8987.23 Da        Isoelectric Point: 4.5338

>AT46622 WP_038636704.1 NZ_CP007557:1843240-1843488 [Citrobacter freundii CFNIH1]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIQVSLN
DL

Download         Length: 249 bp

>AT46622 NZ_CP007557:1843240-1843488 [Citrobacter freundii CFNIH1]
ATGCCATTTCACATACTGACCAAAACTGCAGCCAGCATCACCGACCTGAAACGTAACCCGATGGGGACGGTTAACGCAGG
GGAAGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCAGCGTTTTACTGCGTGCCGCCTGCGGTCTATGCGTATTTGC
TGGAGCTGGCAGAAGATGCGGAGCTGAACCGTATCGCCGACGAACGTGAAGGTGGAAAGCGAATACAGGTGTCTTTAAAT
GACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3WY74

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3X2E3

References