Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 1270917..1271664 | Replicon | chromosome |
Accession | NZ_CP007557 | ||
Organism | Citrobacter freundii CFNIH1 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A376QBB8 |
Locus tag | CFNIH1_RS06110 | Protein ID | WP_038635535.1 |
Coordinates | 1271287..1271664 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | - |
Locus tag | CFNIH1_RS06105 | Protein ID | WP_155268626.1 |
Coordinates | 1270917..1271240 (+) | Length | 108 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CFNIH1_RS06070 | 1266837..1267534 | + | 698 | Protein_1194 | IS1 family transposase | - |
CFNIH1_RS06075 | 1267531..1267980 | + | 450 | WP_080700391.1 | hypothetical protein | - |
CFNIH1_RS27920 | 1268100..1268273 | + | 174 | WP_000088744.1 | DUF905 family protein | - |
CFNIH1_RS06080 | 1268373..1269194 | + | 822 | WP_038635526.1 | DUF945 domain-containing protein | - |
CFNIH1_RS06085 | 1269194..1269439 | + | 246 | WP_000680586.1 | hypothetical protein | - |
CFNIH1_RS06090 | 1269533..1270006 | + | 474 | WP_000855059.1 | antirestriction protein | - |
CFNIH1_RS06095 | 1270022..1270498 | + | 477 | WP_001186768.1 | RadC family protein | - |
CFNIH1_RS06100 | 1270567..1270788 | + | 222 | WP_000692306.1 | DUF987 domain-containing protein | - |
CFNIH1_RS06105 | 1270917..1271240 | + | 324 | WP_155268626.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
CFNIH1_RS06110 | 1271287..1271664 | + | 378 | WP_038635535.1 | TA system toxin CbtA family protein | Toxin |
CFNIH1_RS06115 | 1271661..1272149 | + | 489 | WP_038635538.1 | hypothetical protein | - |
CFNIH1_RS06120 | 1272116..1272358 | + | 243 | WP_012777794.1 | DUF957 domain-containing protein | - |
CFNIH1_RS06125 | 1272443..1272631 | + | 189 | Protein_1206 | restriction endonuclease subunit M | - |
CFNIH1_RS06130 | 1272826..1274367 | + | 1542 | Protein_1207 | IS21-like element ISEc12 family transposase | - |
CFNIH1_RS06135 | 1274382..1275128 | + | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
CFNIH1_RS06140 | 1275210..1275590 | + | 381 | Protein_1209 | DUF4942 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catA1 / ant(2'')-Ia / catB3 / qacE / sul1 / dfrA19 / blaOXA-1 / ant(3'')-Ia | - | 1231517..1279443 | 47926 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14016.93 Da Isoelectric Point: 7.3223
>T46620 WP_038635535.1 NZ_CP007557:1271287-1271664 [Citrobacter freundii CFNIH1]
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T46620 NZ_CP007557:1271287-1271664 [Citrobacter freundii CFNIH1]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 11714.51 Da Isoelectric Point: 6.4629
>AT46620 WP_155268626.1 NZ_CP007557:1270917-1271240 [Citrobacter freundii CFNIH1]
MVGGPCTVTPCFGARLVQEGNRLHYLVDRAGIRGRFSDADAYHLDQAFLLLMKQLELMLTSGELNPRHQHTVTLYAKELT
CEADTLGSCGYVYLAVYPTPAAPAITV
MVGGPCTVTPCFGARLVQEGNRLHYLVDRAGIRGRFSDADAYHLDQAFLLLMKQLELMLTSGELNPRHQHTVTLYAKELT
CEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 324 bp
>AT46620 NZ_CP007557:1270917-1271240 [Citrobacter freundii CFNIH1]
CTGGTGGGGGGGCCCTGCACCGTGACGCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAATCGGTTGCATTACCTTGT
CGACCGTGCCGGTATCAGAGGCCGGTTCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCTGCTGCTGATGAAAC
AACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGAGCTGACC
TGCGAAGCCGATACCCTTGGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGT
ATAA
CTGGTGGGGGGGCCCTGCACCGTGACGCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAATCGGTTGCATTACCTTGT
CGACCGTGCCGGTATCAGAGGCCGGTTCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCTGCTGCTGATGAAAC
AACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGAGCTGACC
TGCGAAGCCGATACCCTTGGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGT
ATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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