46620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1270917..1271664 Replicon chromosome
Accession NZ_CP007557
Organism Citrobacter freundii CFNIH1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376QBB8
Locus tag CFNIH1_RS06110 Protein ID WP_038635535.1
Coordinates 1271287..1271664 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CFNIH1_RS06105 Protein ID WP_155268626.1
Coordinates 1270917..1271240 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFNIH1_RS06070 1266837..1267534 + 698 Protein_1194 IS1 family transposase -
CFNIH1_RS06075 1267531..1267980 + 450 WP_080700391.1 hypothetical protein -
CFNIH1_RS27920 1268100..1268273 + 174 WP_000088744.1 DUF905 family protein -
CFNIH1_RS06080 1268373..1269194 + 822 WP_038635526.1 DUF945 domain-containing protein -
CFNIH1_RS06085 1269194..1269439 + 246 WP_000680586.1 hypothetical protein -
CFNIH1_RS06090 1269533..1270006 + 474 WP_000855059.1 antirestriction protein -
CFNIH1_RS06095 1270022..1270498 + 477 WP_001186768.1 RadC family protein -
CFNIH1_RS06100 1270567..1270788 + 222 WP_000692306.1 DUF987 domain-containing protein -
CFNIH1_RS06105 1270917..1271240 + 324 WP_155268626.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CFNIH1_RS06110 1271287..1271664 + 378 WP_038635535.1 TA system toxin CbtA family protein Toxin
CFNIH1_RS06115 1271661..1272149 + 489 WP_038635538.1 hypothetical protein -
CFNIH1_RS06120 1272116..1272358 + 243 WP_012777794.1 DUF957 domain-containing protein -
CFNIH1_RS06125 1272443..1272631 + 189 Protein_1206 restriction endonuclease subunit M -
CFNIH1_RS06130 1272826..1274367 + 1542 Protein_1207 IS21-like element ISEc12 family transposase -
CFNIH1_RS06135 1274382..1275128 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
CFNIH1_RS06140 1275210..1275590 + 381 Protein_1209 DUF4942 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catA1 / ant(2'')-Ia / catB3 / qacE / sul1 / dfrA19 / blaOXA-1 / ant(3'')-Ia - 1231517..1279443 47926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(5-99)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14016.93 Da        Isoelectric Point: 7.3223

>T46620 WP_038635535.1 NZ_CP007557:1271287-1271664 [Citrobacter freundii CFNIH1]
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T46620 NZ_CP007557:1271287-1271664 [Citrobacter freundii CFNIH1]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11714.51 Da        Isoelectric Point: 6.4629

>AT46620 WP_155268626.1 NZ_CP007557:1270917-1271240 [Citrobacter freundii CFNIH1]
MVGGPCTVTPCFGARLVQEGNRLHYLVDRAGIRGRFSDADAYHLDQAFLLLMKQLELMLTSGELNPRHQHTVTLYAKELT
CEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 324 bp

>AT46620 NZ_CP007557:1270917-1271240 [Citrobacter freundii CFNIH1]
CTGGTGGGGGGGCCCTGCACCGTGACGCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAATCGGTTGCATTACCTTGT
CGACCGTGCCGGTATCAGAGGCCGGTTCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCTGCTGCTGATGAAAC
AACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGAGCTGACC
TGCGAAGCCGATACCCTTGGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGT
ATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A376QBB8


Antitoxin

Source ID Structure

References