Detailed information of TA system TA046619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 435884..437582
• Replicon: chromosome
• Accession: NZ_CP007557
• Organism: Citrobacter freundii CFNIH1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: CFNIH1_RS02110
• Protein ID: WP_038633789.1
• Coordinates: 436653..437582 (+)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: CFNIH1_RS02105
• Protein ID: WP_038633786.1
• Coordinates: 435884..436666 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFNIH1_RS02090	431415..431621	-	207	WP_038633780.1	helix-turn-helix domain-containing protein	-
CFNIH1_RS02095	431618..432079	-	462	Protein_411	hypothetical protein	-
CFNIH1_RS02100	432403..435618	-	3216	WP_038633783.1	RNA-directed DNA polymerase	-
CFNIH1_RS02105	435884..436666	+	783	WP_038633786.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
CFNIH1_RS02110	436653..437582	+	930	WP_038633789.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
CFNIH1_RS02115	437807..438964	-	1158	WP_038633793.1	hypothetical protein	-
CFNIH1_RS02120	438966..440867	-	1902	Protein_416	hypothetical protein	-
CFNIH1_RS02125	441252..441965	-	714	Protein_417	ImpA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	419538..443301	23763

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-275)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35090.30 Da
• Isoelectric Point: 5.4632

>T46619 WP_038633789.1 NZ_CP007557:436653-437582 [Citrobacter freundii CFNIH1]
MDLRDSYARQVRLLMTALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDSDLAAINDALMRITESLNGR
PGINAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPATEMPVCEQVEMEYGFTTMNVVSQADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWETARIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
QSHLTDRDRQFLLSYKQNTPDWSLYRYPEIQHLPAIRWKLRNLAVLKEKNPAKYAATVNKLEGVLEQYF

Nucleotide

• Length: 930 bp

>T46619 NZ_CP007557:436653-437582 [Citrobacter freundii CFNIH1]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTCAGACTATTAATGACTGCCCTGCCGTATGTGGCAAAGGAGTCCTGCTT
CGCGCTGAAAGGCGGCACGGCAATCAATTTGTTTGTACAGGATTTTCCTCGCCTGTCGGTGGATATCGATCTGGCGTATA
AGACCTATGCGGATCGCGATTCCGATCTGGCTGCGATCAATGATGCCTTGATGCGTATTACTGAATCACTGAACGGCAGA
CCGGGGATCAACGCTATCCGGCAGGAGAACAAAGCGGATGAAAAGCGCATTATCGTTAACACCGCCGACGCGCAGATAAA
GATTGAAGTTAGTCCAGTCTGGCGTGGGCTGCTGTTGCCAGCAACAGAAATGCCGGTATGTGAACAGGTGGAAATGGAGT
ATGGCTTCACCACGATGAATGTCGTCTCGCAGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTGCTGAATATGCTGGAGAAACCGGGGCTGACGCGCGAGATCTTTGACGGCTTTCTTTGTTA
TCTGGCAGGACATCCCCGCCCCATTGCCGAGCTGCTGGCACCAAACTGGGAAACAGCGCGGATCGCTACTTTGTACGCAC
AGGAATTTTCAGGAATGACACAGCAGGAAACGTCGCTGGAGTCCCTTTTATCAGTAACGACATTGCTGCCACAAGCGCTG
CAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCAGCTATAAGCAAAATACCCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAGCACCTACCGGCCATTCGCTGGAAACTGCGTAATCTGGCGGTACTGAAGGAAAAGAACCCGGCCAAGT
ATGCGGCGACGGTGAACAAGTTAGAAGGCGTTCTGGAGCAGTACTTTTAG

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29385.59 Da
• Isoelectric Point: 8.6064

>AT46619 WP_038633786.1 NZ_CP007557:435884-436666 [Citrobacter freundii CFNIH1]
MPNYINWLMQNTLPGQVLLQSWLTRSGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWERPVRVAGLT
SLALQGHAHYTEPGRQQIWLALPAYVKLPGWFAAFEQSAMFVTLYTSGLTVDIPSFTTQLNIGDRQLTGSVPELAAYEIA
YGVPSFISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVLLYLARRNAHPYFRHLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT46619 NZ_CP007557:435884-436666 [Citrobacter freundii CFNIH1]
TTGCCAAACTATATAAACTGGCTGATGCAAAACACCCTACCCGGTCAGGTGTTGCTCCAGTCATGGCTTACCCGCAGCGG
CATAGATCGTAAGCTCTCTTACCTCTATGTTCAGAATGGCTGGCTAAGGCGGATTGCGCACGGCGTATACTGCCGGACAG
GCCGTGAACCAGACTGGGTTGACGCGGTTTACTGCCTGCAAACGCAGTGGGAAAGACCGGTTCGCGTGGCGGGGCTGACC
AGCCTTGCGTTACAGGGTCATGCTCACTATACCGAGCCGGGCAGGCAGCAAATCTGGCTCGCGCTTCCGGCTTATGTCAA
GCTGCCGGGATGGTTCGCCGCCTTTGAACAATCCGCGATGTTTGTCACGCTGTATACCTCTGGCCTCACCGTTGATATAC
CGTCATTCACGACACAACTGAATATCGGCGACCGACAGTTAACAGGTAGTGTCCCAGAACTGGCCGCGTATGAAATAGCC
TACGGTGTTCCTTCGTTTATCTCGTTCGAACATGCCGACGCTCTATTTCAGGGAATGAATCTTCTCAGCCCGCGTAAATT
ACAAACACTGCTCTGCGCCAGTCATTCGGTTAAAACCAACCGGGTGCTGCTTTACCTTGCCCGACGCAATGCGCATCCTT
ATTTTCGGCATCTCGATCAAAGCGGCATAGAAACAGGTACAGGAAAACGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA