Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 428506..429345 | Replicon | chromosome |
| Accession | NZ_CP007557 | ||
| Organism | Citrobacter freundii CFNIH1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2Z3WYV4 |
| Locus tag | CFNIH1_RS02070 | Protein ID | WP_038633771.1 |
| Coordinates | 428968..429345 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | CFNIH1_RS02065 | Protein ID | WP_077249796.1 |
| Coordinates | 428506..428919 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CFNIH1_RS02025 | 423597..424484 | + | 888 | WP_038633742.1 | 50S ribosome-binding GTPase | - |
| CFNIH1_RS02030 | 424690..425091 | + | 402 | WP_000819262.1 | hypothetical protein | - |
| CFNIH1_RS02035 | 425188..425655 | + | 468 | WP_000727137.1 | hypothetical protein | - |
| CFNIH1_RS26140 | 425846..426096 | + | 251 | Protein_399 | DUF905 family protein | - |
| CFNIH1_RS02040 | 426212..427030 | + | 819 | WP_001234374.1 | DUF945 domain-containing protein | - |
| CFNIH1_RS02045 | 427030..427293 | + | 264 | WP_038633754.1 | hypothetical protein | - |
| CFNIH1_RS02050 | 427371..427766 | + | 396 | WP_051594539.1 | antirestriction protein | - |
| CFNIH1_RS02055 | 427819..428304 | + | 486 | WP_038642868.1 | DNA repair protein RadC | - |
| CFNIH1_RS02060 | 428316..428537 | + | 222 | WP_038633763.1 | DUF987 domain-containing protein | - |
| CFNIH1_RS02065 | 428506..428919 | + | 414 | WP_077249796.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CFNIH1_RS02070 | 428968..429345 | + | 378 | WP_038633771.1 | TA system toxin CbtA family protein | Toxin |
| CFNIH1_RS02075 | 429342..429833 | + | 492 | WP_038633774.1 | hypothetical protein | - |
| CFNIH1_RS02080 | 429863..430057 | + | 195 | WP_038633777.1 | DUF957 domain-containing protein | - |
| CFNIH1_RS02085 | 430138..430987 | + | 850 | Protein_409 | DUF4942 domain-containing protein | - |
| CFNIH1_RS02090 | 431415..431621 | - | 207 | WP_038633780.1 | helix-turn-helix domain-containing protein | - |
| CFNIH1_RS02095 | 431618..432079 | - | 462 | Protein_411 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 419538..443301 | 23763 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14050.89 Da Isoelectric Point: 6.8604
>T46618 WP_038633771.1 NZ_CP007557:428968-429345 [Citrobacter freundii CFNIH1]
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRTVTDITTGKYSKMTR
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRTVTDITTGKYSKMTR
Download Length: 378 bp
>T46618 NZ_CP007557:428968-429345 [Citrobacter freundii CFNIH1]
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAACGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAACGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15178.32 Da Isoelectric Point: 7.7885
>AT46618 WP_077249796.1 NZ_CP007557:428506-428919 [Citrobacter freundii CFNIH1]
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIAIYPTPSVTS
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIAIYPTPSVTS
Download Length: 414 bp
>AT46618 NZ_CP007557:428506-428919 [Citrobacter freundii CFNIH1]
ATGTCGTTCTGCGCAGCGTCACCCTCAGTTAACTCATATTCAAGGAGCACGACCTTGTTGAATAAAACACTGCCGGCAAA
TCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTTCGGTGCACGGCTGGTACAGGAAGGCA
ACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACGCGGATTTGCGCCATCTCGACCAAGCG
TTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGTCCCCGCCATCAGCACTGCGTCACGCT
GTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATATCTATATAGCGATTTATCCGACACCAT
CAGTAACGTCATAA
ATGTCGTTCTGCGCAGCGTCACCCTCAGTTAACTCATATTCAAGGAGCACGACCTTGTTGAATAAAACACTGCCGGCAAA
TCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTTCGGTGCACGGCTGGTACAGGAAGGCA
ACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACGCGGATTTGCGCCATCTCGACCAAGCG
TTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGTCCCCGCCATCAGCACTGCGTCACGCT
GTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATATCTATATAGCGATTTATCCGACACCAT
CAGTAACGTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|