Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 3845564..3846225 Replicon chromosome
Accession NZ_CP007546
Organism Enterobacter asburiae L1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DI57_RS18150 Protein ID WP_029740768.1
Coordinates 3845564..3845962 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DI57_RS18155 Protein ID WP_029740767.1
Coordinates 3845959..3846225 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DI57_RS18120 3841300..3841530 - 231 WP_155249580.1 hypothetical protein -
DI57_RS18125 3841621..3842076 - 456 WP_029740773.1 hypothetical protein -
DI57_RS18130 3842380..3842628 - 249 WP_029740772.1 hypothetical protein -
DI57_RS18135 3842741..3843694 - 954 WP_029740771.1 helix-turn-helix domain-containing protein -
DI57_RS18140 3843721..3844500 - 780 WP_029740770.1 MBL fold metallo-hydrolase -
DI57_RS18145 3844623..3845423 - 801 WP_029740769.1 lipoprotein NlpA -
DI57_RS18150 3845564..3845962 - 399 WP_029740768.1 type II toxin-antitoxin system VapC family toxin Toxin
DI57_RS18155 3845959..3846225 - 267 WP_029740767.1 virulence protein Antitoxin
DI57_RS18160 3846355..3846774 - 420 WP_029740766.1 GNAT family N-acetyltransferase -
DI57_RS18165 3846961..3847530 + 570 WP_029740765.1 TetR/AcrR family transcriptional regulator -
DI57_RS18170 3847679..3848800 + 1122 WP_029740764.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14948.13 Da        Isoelectric Point: 6.4785

>T46614 WP_029740768.1 NZ_CP007546:c3845962-3845564 [Enterobacter asburiae L1]
MRHMLDTNIVSHLFKRHPEVISRMTCLTPGDVCISSITEAELLYGADKKKSSRLKETIQEFLNTITICDWDSEAAATYGE
LRAAMEKRGKVMGDLDQLIAAHAISRRTTIVTNDRAFRMVQELTVEDWTTTS

Download         Length: 399 bp

>T46614 NZ_CP007546:c3845962-3845564 [Enterobacter asburiae L1]
ATGAGGCATATGCTGGATACGAATATCGTGAGCCACTTGTTTAAACGACACCCGGAAGTTATAAGCAGAATGACATGTTT
GACTCCGGGGGACGTTTGTATCTCAAGCATTACCGAAGCAGAGTTGCTGTATGGTGCTGATAAGAAGAAAAGCAGTAGAT
TGAAAGAAACAATCCAGGAGTTTCTCAATACCATAACGATTTGCGACTGGGATAGTGAAGCCGCCGCAACGTATGGTGAA
CTCCGCGCAGCAATGGAGAAGAGAGGAAAAGTGATGGGCGATCTCGATCAACTGATCGCTGCGCATGCCATCAGTCGGAG
AACAACGATTGTGACTAACGATCGTGCATTCAGAATGGTGCAGGAGCTTACCGTCGAGGACTGGACGACAACGTCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10028.34 Da        Isoelectric Point: 5.8481

>AT46614 WP_029740767.1 NZ_CP007546:c3846225-3845959 [Enterobacter asburiae L1]
MERTAKLFKKGRHQAVMLPAEFAFDTESVYIRRDEEGNVVLAAKPVQTKSWDTFFRMLSVTDVPDSFLSKEERNQSVTTR
DPLDGACS

Download         Length: 267 bp

>AT46614 NZ_CP007546:c3846225-3845959 [Enterobacter asburiae L1]
ATGGAACGCACAGCAAAACTCTTCAAAAAGGGGCGGCATCAGGCCGTAATGCTACCTGCTGAATTCGCTTTTGATACGGA
GAGCGTCTACATCCGGCGGGATGAGGAGGGGAATGTCGTTTTGGCGGCAAAACCTGTTCAGACAAAGAGTTGGGATACGT
TTTTCCGCATGCTGTCAGTTACGGACGTACCGGATTCGTTTCTGAGCAAAGAGGAACGCAATCAGAGTGTTACGACAAGA
GACCCTCTGGATGGAGCATGTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References