Detailed information of TA system TA046613

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3417495..3418011
• Replicon: chromosome
• Accession: NZ_CP007546
• Organism: Enterobacter asburiae L1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DI57_RS16060
• Protein ID: WP_029739265.1
• Coordinates: 3417495..3417779 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8E1RL94
• Locus tag: DI57_RS16065
• Protein ID: WP_023331889.1
• Coordinates: 3417769..3418011 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DI57_RS16045	3412772..3414415	+	1644	WP_029739267.1	alpha,alpha-phosphotrehalase	-
DI57_RS16050	3414791..3416929	+	2139	WP_023310191.1	anaerobic ribonucleoside-triphosphate reductase	-
DI57_RS16055	3417027..3417491	+	465	WP_029739266.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
DI57_RS16060	3417495..3417779	-	285	WP_029739265.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DI57_RS16065	3417769..3418011	-	243	WP_023331889.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DI57_RS16070	3418089..3419999	-	1911	WP_029739264.1	BglG family transcription antiterminator	-
DI57_RS16075	3420019..3421155	-	1137	WP_029739263.1	lactonase family protein	-
DI57_RS16080	3421239..3421979	-	741	WP_029739262.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10873.72 Da
• Isoelectric Point: 10.3350

>T46613 WP_029739265.1 NZ_CP007546:c3417779-3417495 [Enterobacter asburiae L1]
MTYELAFDPRALKEWSKLGQTVKDQLKKKLAEVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T46613 NZ_CP007546:c3417779-3417495 [Enterobacter asburiae L1]
ATGACTTATGAACTGGCATTTGACCCGAGGGCGTTAAAGGAGTGGAGTAAGCTGGGGCAGACTGTAAAAGACCAGTTAAA
GAAGAAACTTGCGGAGGTGTTGGTGAACCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGATCGCAGGGTTATCGTCTGGTCTATCAGGTTCAGGACAATGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
AGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9030.41 Da
• Isoelectric Point: 4.7719

>AT46613 WP_023331889.1 NZ_CP007546:c3418011-3417769 [Enterobacter asburiae L1]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDELIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT46613 NZ_CP007546:c3418011-3417769 [Enterobacter asburiae L1]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GTGAAGATGAATTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATTAAGGTTAGTCTGGATGACTTA
TGA