Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2850102..2850722 Replicon chromosome
Accession NZ_CP007546
Organism Enterobacter asburiae L1

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag DI57_RS13430 Protein ID WP_008499287.1
Coordinates 2850504..2850722 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag DI57_RS13425 Protein ID WP_008499288.1
Coordinates 2850102..2850476 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DI57_RS13415 2845229..2846422 + 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DI57_RS13420 2846445..2849591 + 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit -
DI57_RS13425 2850102..2850476 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
DI57_RS13430 2850504..2850722 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
DI57_RS13435 2850928..2851479 + 552 WP_023310599.1 maltose O-acetyltransferase -
DI57_RS13440 2851597..2852064 + 468 WP_029741965.1 membrane protein -
DI57_RS13445 2852036..2853496 - 1461 WP_029741966.1 PLP-dependent aminotransferase family protein -
DI57_RS13450 2853598..2854308 + 711 WP_023310596.1 GNAT family N-acetyltransferase -
DI57_RS13455 2854305..2854445 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
DI57_RS13460 2854448..2854708 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T46612 WP_008499287.1 NZ_CP007546:2850504-2850722 [Enterobacter asburiae L1]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T46612 NZ_CP007546:2850504-2850722 [Enterobacter asburiae L1]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT46612 WP_008499288.1 NZ_CP007546:2850102-2850476 [Enterobacter asburiae L1]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT46612 NZ_CP007546:2850102-2850476 [Enterobacter asburiae L1]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References