Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 169339..169996 Replicon chromosome
Accession NZ_CP007546
Organism Enterobacter asburiae L1

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag DI57_RS00870 Protein ID WP_021242050.1
Coordinates 169586..169996 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag DI57_RS00865 Protein ID WP_010435322.1
Coordinates 169339..169605 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DI57_RS00835 164520..165953 - 1434 WP_029739205.1 6-phospho-beta-glucosidase BglA -
DI57_RS00840 166070..166801 - 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
DI57_RS00845 166853..167164 + 312 WP_029739203.1 N(4)-acetylcytidine aminohydrolase -
DI57_RS00855 167330..167989 + 660 WP_023309101.1 hemolysin III family protein -
DI57_RS00860 168064..169044 - 981 WP_029739202.1 tRNA-modifying protein YgfZ -
DI57_RS00865 169339..169605 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
DI57_RS00870 169586..169996 + 411 WP_021242050.1 protein YgfX Toxin
DI57_RS00875 170003..170524 - 522 WP_023309099.1 flavodoxin FldB -
DI57_RS00880 170626..171522 + 897 WP_023333303.1 site-specific tyrosine recombinase XerD -
DI57_RS00885 171551..172264 + 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DI57_RS00890 172270..174003 + 1734 WP_029740339.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T46601 WP_021242050.1 NZ_CP007546:169586-169996 [Enterobacter asburiae L1]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T46601 NZ_CP007546:169586-169996 [Enterobacter asburiae L1]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCTCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCAGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT46601 WP_010435322.1 NZ_CP007546:169339-169605 [Enterobacter asburiae L1]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT46601 NZ_CP007546:169339-169605 [Enterobacter asburiae L1]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TGTTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References