Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 3065757..3066386 Replicon chromosome
Accession NZ_CP007542
Organism Synechocystis sp. PCC 6714

Toxin (Protein)


Gene name vapC Uniprot ID A0A068N690
Locus tag D082_RS13950 Protein ID WP_028947055.1
Coordinates 3065985..3066386 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A068MZW5
Locus tag D082_RS13945 Protein ID WP_028947056.1
Coordinates 3065757..3065984 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D082_RS13920 3061870..3062142 + 273 WP_028947061.1 BrnT family toxin -
D082_RS13925 3062145..3062468 + 324 WP_051738883.1 hypothetical protein -
D082_RS13930 3062529..3062744 + 216 WP_028947059.1 type II toxin-antitoxin system HicA family toxin -
D082_RS13935 3062747..3062953 + 207 WP_028947058.1 type II toxin-antitoxin system HicB family antitoxin -
D082_RS13940 3062983..3065724 + 2742 WP_038531014.1 class I SAM-dependent DNA methyltransferase -
D082_RS13945 3065757..3065984 + 228 WP_028947056.1 virulence factor Antitoxin
D082_RS13950 3065985..3066386 + 402 WP_028947055.1 type II toxin-antitoxin system VapC family toxin Toxin
D082_RS13955 3066521..3066751 + 231 WP_028947054.1 hypothetical protein -
D082_RS13960 3067070..3067288 + 219 WP_028947053.1 hypothetical protein -
D082_RS13965 3067285..3067566 + 282 WP_028947052.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
D082_RS13970 3067660..3067989 + 330 WP_202963086.1 nucleotidyltransferase family protein -
D082_RS13975 3067979..3068179 + 201 WP_202963087.1 hypothetical protein -
D082_RS13980 3068232..3068531 + 300 WP_028947050.1 nucleotidyltransferase domain-containing protein -
D082_RS18820 3068656..3068856 + 201 WP_202963115.1 DUF86 domain-containing protein -
D082_RS13985 3069236..3069985 + 750 WP_028947049.1 urea ABC transporter ATP-binding subunit UrtE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15002.43 Da        Isoelectric Point: 5.8959

>T46600 WP_028947055.1 NZ_CP007542:3065985-3066386 [Synechocystis sp. PCC 6714]
MKYLLDTNIRIYLIKKKPLQVLAKFQTLEVSEIGISSITVAELEYGVSKSQQQSKNRDALMQFLIPLEIIEFNQEAAIAY
GNIRSNLESRGLVIGAMDMLIAAHALSLEVTLVSNNVREFSRISNLFLENRAE

Download         Length: 402 bp

>T46600 NZ_CP007542:3065985-3066386 [Synechocystis sp. PCC 6714]
ATGAAATACTTACTAGATACAAATATTCGCATTTATCTAATTAAGAAGAAGCCGCTCCAAGTCTTGGCAAAATTTCAAAC
CCTAGAAGTGTCAGAAATTGGTATTTCATCCATTACCGTAGCAGAATTAGAATATGGTGTCAGTAAAAGTCAACAGCAAT
CGAAAAACCGTGATGCCTTGATGCAGTTCTTGATTCCGCTAGAAATCATTGAGTTTAATCAAGAAGCGGCGATCGCCTAT
GGCAATATCAGAAGTAATCTGGAAAGTAGAGGTCTTGTCATTGGGGCTATGGATATGCTGATTGCGGCCCATGCGTTAAG
TCTGGAAGTAACTCTTGTGAGCAATAATGTTCGAGAATTTTCACGCATTAGCAATTTATTCTTGGAAAACCGGGCAGAAT
AA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8484.55 Da        Isoelectric Point: 4.1789

>AT46600 WP_028947056.1 NZ_CP007542:3065757-3065984 [Synechocystis sp. PCC 6714]
MNTAQISNDGSHQIVILPEGFKLSGTEVYIKKVGNTVVLISKDNPWQSLIESLDQFSDDFMATREQLPLDVREEF

Download         Length: 228 bp

>AT46600 NZ_CP007542:3065757-3065984 [Synechocystis sp. PCC 6714]
ATGAACACCGCCCAAATTAGTAACGATGGTTCTCATCAAATTGTAATACTCCCCGAAGGCTTCAAATTGTCGGGTACTGA
GGTTTACATTAAAAAAGTTGGAAACACGGTTGTTTTAATCTCGAAAGATAACCCTTGGCAATCCTTGATTGAAAGCTTAG
ATCAATTCTCAGATGACTTTATGGCAACTAGGGAACAGCTTCCCCTCGATGTGCGAGAAGAATTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068N690

Antitoxin

Source ID Structure
AlphaFold DB A0A068MZW5

References