Detailed information of TA system TA046598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 502927..503565
• Replicon: chromosome
• Accession: NZ_CP007542
• Organism: Synechocystis sp. PCC 6714

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D082_RS02295
• Protein ID: WP_028949374.1
• Coordinates: 503170..503565 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D082_RS02290
• Protein ID: WP_028949375.1
• Coordinates: 502927..503166 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D082_RS02285	501374..502744	+	1371	WP_028949376.1	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	-
D082_RS02290	502927..503166	+	240	WP_028949375.1	DUF2281 domain-containing protein	Antitoxin
D082_RS02295	503170..503565	+	396	WP_028949374.1	type II toxin-antitoxin system VapC family toxin	Toxin
D082_RS02300	503605..505752	-	2148	WP_028949373.1	glycine--tRNA ligase subunit beta	-
D082_RS02305	505988..507073	+	1086	WP_028949372.1	glucose-1-phosphate thymidylyltransferase	-
D082_RS02310	507332..508027	+	696	WP_028949371.1	aldehyde oxygenase (deformylating)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-127)

Antitoxin

• Domain of unknown function DUF2281 (6-78)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15492.89 Da
• Isoelectric Point: 6.8488

>T46598 WP_028949374.1 NZ_CP007542:503170-503565 [Synechocystis sp. PCC 6714]
MQVILDTHVFIWYIEGNQKLSPPLRHVIEFAADEIYLSIVSLWEIAIKLSINKLRLNYAFAGLENLLANLNISVLNITWQ
HLEAYRNLPLHHRDPFDRMIIAQAQHHNFSVISKDGNFKKYNVNLIWEWEQ

Nucleotide

• Length: 396 bp

>T46598 NZ_CP007542:503170-503565 [Synechocystis sp. PCC 6714]
ATGCAAGTTATTTTAGACACGCATGTTTTTATTTGGTACATCGAGGGAAATCAAAAACTTTCTCCACCACTGAGGCATGT
GATTGAATTTGCGGCCGATGAGATTTATTTGAGCATCGTTAGTCTCTGGGAGATTGCTATTAAACTCAGCATCAACAAAC
TGAGGCTCAATTATGCATTTGCTGGTCTAGAGAATTTGCTTGCTAATCTCAATATTTCGGTTTTGAACATCACATGGCAA
CATTTGGAAGCTTATCGAAATTTGCCCTTGCATCACCGGGATCCCTTTGACCGCATGATTATCGCCCAGGCTCAGCACCA
CAATTTTTCCGTCATTAGCAAAGACGGGAATTTCAAAAAATACAACGTTAATTTAATCTGGGAATGGGAACAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9024.32 Da
• Isoelectric Point: 4.5950

>AT46598 WP_028949375.1 NZ_CP007542:502927-503166 [Synechocystis sp. PCC 6714]
MTDTALLEKINALPDAMKLEVEHFVEFLLAKQTHISPEQALSSHQTNTSKKRDGFGILKGKIWMADDFDAPLEEMQEYM

Nucleotide

• Length: 240 bp

>AT46598 NZ_CP007542:502927-503166 [Synechocystis sp. PCC 6714]
ATGACAGACACGGCCCTACTAGAAAAAATTAATGCCCTCCCCGATGCCATGAAACTTGAGGTGGAACACTTTGTCGAGTT
TTTATTGGCTAAGCAGACACACATCAGTCCAGAACAAGCTCTATCTAGCCATCAGACCAATACCAGTAAAAAACGAGATG
GCTTTGGTATCCTTAAGGGAAAGATTTGGATGGCGGATGACTTTGATGCTCCATTAGAAGAAATGCAGGAGTATATGTAA