Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1493183..1493660 Replicon chromosome
Accession NZ_CP007539
Organism Staphylococcus aureus strain FDAARGOS_5

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag X998_RS07885 Protein ID WP_000052077.1
Coordinates 1493472..1493660 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag X998_RS07880 Protein ID WP_001059690.1
Coordinates 1493183..1493443 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X998_RS07845 1488576..1489292 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
X998_RS07850 1489440..1489862 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
X998_RS07855 1490261..1490755 + 495 WP_000569886.1 GNAT family N-acetyltransferase -
X998_RS07860 1490910..1491527 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
X998_RS07865 1491600..1492181 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
X998_RS07870 1492406..1492642 + 237 WP_000368687.1 hypothetical protein -
X998_RS07875 1492639..1492842 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
X998_RS07880 1493183..1493443 + 261 WP_001059690.1 hypothetical protein Antitoxin
X998_RS07885 1493472..1493660 + 189 WP_000052077.1 hypothetical protein Toxin
X998_RS07890 1493848..1494417 + 570 WP_001106654.1 hypothetical protein -
X998_RS07895 1494505..1494789 + 285 WP_001004395.1 hypothetical protein -
X998_RS07900 1494851..1495069 + 219 WP_000005886.1 hypothetical protein -
X998_RS07905 1495565..1495765 - 201 WP_001059082.1 cold-shock protein -
X998_RS07910 1496122..1496808 - 687 WP_001548082.1 thermonuclease family protein -
X998_RS07915 1497149..1497619 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / selq / selk / vWbp 1465712..1511512 45800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T46590 WP_000052077.1 NZ_CP007539:1493472-1493660 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46590 NZ_CP007539:1493472-1493660 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTATCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46590 WP_001059690.1 NZ_CP007539:1493183-1493443 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46590 NZ_CP007539:1493183-1493443 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References