Detailed information of TA system TA046589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1475514..1476046
• Replicon: chromosome
• Accession: NZ_CP007539
• Organism: Staphylococcus aureus strain FDAARGOS_5

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: X998_RS07730
• Protein ID: WP_001103942.1
• Coordinates: 1475514..1475834 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: X998_RS07735
• Protein ID: WP_001058486.1
• Coordinates: 1475837..1476046 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X998_RS07700	1470662..1471003	-	342	WP_001190615.1	hypothetical protein	-
X998_RS07705	1471520..1472161	-	642	WP_001019764.1	hypothetical protein	-
X998_RS07710	1472158..1472442	-	285	WP_000998181.1	hypothetical protein	-
X998_RS07715	1472444..1472806	-	363	WP_001039168.1	hypothetical protein	-
X998_RS07720	1473107..1474564	-	1458	WP_000390455.1	virulence-associated E family protein	-
X998_RS07725	1474581..1475450	-	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
X998_RS07730	1475514..1475834	-	321	WP_001103942.1	DUF1474 family protein	Toxin
X998_RS07735	1475837..1476046	-	210	WP_001058486.1	hypothetical protein	Antitoxin
X998_RS07740	1476039..1476185	-	147	WP_000784875.1	hypothetical protein	-
X998_RS07745	1476197..1476469	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
X998_RS07750	1476462..1476725	-	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
X998_RS07755	1476918..1477250	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
X998_RS07760	1477262..1477720	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
X998_RS07765	1477737..1478168	+	432	WP_001228759.1	hypothetical protein	-
X998_RS07770	1478238..1478966	+	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
X998_RS07775	1478990..1479718	+	729	WP_000733775.1	staphylococcal enterotoxin type K	-
X998_RS07780	1479807..1481027	+	1221	WP_000266157.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk / vWbp	1465712..1511512	45800

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T46589 WP_001103942.1 NZ_CP007539:c1475834-1475514 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T46589 NZ_CP007539:c1475834-1475514 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT46589 WP_001058486.1 NZ_CP007539:c1476046-1475837 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT46589 NZ_CP007539:c1476046-1475837 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4