Detailed information of TA system TA046578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 54496..55021
• Replicon: plasmid p00
• Accession: NZ_CP007529
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis str. CDC_2010K_0968

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: SEEE0968_RS22980
• Protein ID: WP_001159863.1
• Coordinates: 54496..54801 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: SEEE0968_RS22985
• Protein ID: WP_000813641.1
• Coordinates: 54803..55021 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEE0968_RS22940	49875..50435	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
SEEE0968_RS24565	50591..50878	+	288	WP_071530243.1	hypothetical protein	-
SEEE0968_RS22950	51155..51640	-	486	WP_000905606.1	membrane protein	-
SEEE0968_RS22955	51634..52143	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
SEEE0968_RS22960	52147..52860	-	714	WP_000545756.1	EAL domain-containing protein	-
SEEE0968_RS22965	52869..53651	-	783	WP_000082169.1	site-specific integrase	-
SEEE0968_RS22970	53686..54207	-	522	WP_000198608.1	hypothetical protein	-
SEEE0968_RS22975	54204..54494	-	291	WP_001266176.1	hypothetical protein	-
SEEE0968_RS22980	54496..54801	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
SEEE0968_RS22985	54803..55021	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SEEE0968_RS22990	55697..56218	+	522	WP_077681952.1	hypothetical protein	-
SEEE0968_RS25380	56262..56690	-	429	Protein_74	hypothetical protein	-
SEEE0968_RS25020	56702..56997	+	296	Protein_75	cytoplasmic protein	-
SEEE0968_RS23005	57491..58480	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
SEEE0968_RS24575	58807..58968	-	162	WP_015059604.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59369	59369

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (6-104)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T46578 WP_001159863.1 NZ_CP007529:c54801-54496 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T46578 NZ_CP007529:c54801-54496 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT46578 WP_000813641.1 NZ_CP007529:c55021-54803 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT46578 NZ_CP007529:c55021-54803 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6