Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Fic-relB/Fic-DinJ
Location 818629..819581 Replicon chromosome
Accession NZ_CP007520
Organism Mycoplasma yeatsii GM274B

Toxin (Protein)


Gene name Fic Uniprot ID A0A0C5B7F9
Locus tag MYE_RS03625 Protein ID WP_042733544.1
Coordinates 819012..819581 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C5BPZ6
Locus tag MYE_RS03620 Protein ID WP_042733543.1
Coordinates 818629..818901 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYE_RS03600 813655..814572 + 918 WP_052491426.1 hypothetical protein -
MYE_RS03605 814619..815287 - 669 WP_042733540.1 deoxyribose-phosphate aldolase -
MYE_RS03610 815296..816978 - 1683 WP_042733541.1 phospho-sugar mutase -
MYE_RS03615 817236..818549 + 1314 WP_042733542.1 thymidine phosphorylase -
MYE_RS03620 818629..818901 - 273 WP_042733543.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MYE_RS03625 819012..819581 - 570 WP_042733544.1 Fic family protein Toxin
MYE_RS03630 819686..820339 - 654 WP_042733545.1 purine-nucleoside phosphorylase -
MYE_RS03635 820400..821392 - 993 WP_042733546.1 hypothetical protein -
MYE_RS03640 821418..822542 - 1125 WP_042733547.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(36-115)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-86)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21769.18 Da        Isoelectric Point: 5.1825

>T46577 WP_042733544.1 NZ_CP007520:c819581-819012 [Mycoplasma yeatsii GM274B]
MKSNLIEEEHEIKLSVKRCLELDKDILNTFEVGSKGLQQIHKYIFQDVFDFAGEMRKVNIAKNDFMFAPLIFLEQSLKSI
DKMPENTFDEIIDKYVEMNIAHPFREGNGRCTRILDLMLKTKLKLVINKDIDKDSYFDAIIRSSVDDSDMKQLFKEHLTN
KIDDREVFILGIKKSYEYEGFDIKL

Download         Length: 570 bp

>T46577 NZ_CP007520:c819581-819012 [Mycoplasma yeatsii GM274B]
ATGAAATCAAATTTAATTGAAGAAGAACATGAAATAAAACTTTCTGTAAAACGATGTTTAGAATTATGAGATAAAGATAT
TCTCAATACTTTTGAAGTAGGATCTTGAAAAGGTTTACAACAAATTCATAAATACATTTTTCAAGATGTATTTGATTTTG
CTGGAGAAATGAGAAAAGTTAATATAGCAAAAAATGACTTTATGTTTGCTCCGCTTATATTTTTAGAACAAAGTTTGAAA
TCAATTGATAAAATGCCAGAAAATACTTTTGATGAAATTATAGATAAGTATGTTGAAATGAATATAGCTCATCCATTTAG
AGAGGGAAATGGACGTTGTACTAGAATTTGATTAGATTTAATGTTAAAAACAAAACTAAAACTAGTGATCAACTGAAAAG
ATATTGATAAAGATAGTTATTTTGATGCGATTATTAGATCAAGCGTTGACGATTCAGATATGAAACAATTATTTAAAGAA
CATTTAACAAATAAAATTGATGATAGAGAAGTTTTTATTTTAGGAATTAAAAAGTCATATGAATATGAAGGATTTGATAT
TAAATTGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10248.91 Da        Isoelectric Point: 9.5706

>AT46577 WP_042733543.1 NZ_CP007520:c818901-818629 [Mycoplasma yeatsii GM274B]
MKTTNLNIRIDKETKEKAEAIFHELGITTSAAINMFLKAAIRKNTLPFSIELDTPSKETLKAIKEAEELLKDPNTKYHSS
LKEFLKSLEK

Download         Length: 273 bp

>AT46577 NZ_CP007520:c818901-818629 [Mycoplasma yeatsii GM274B]
ATGAAGACAACAAATTTAAATATAAGAATTGACAAGGAAACTAAAGAAAAAGCAGAAGCTATATTTCACGAACTAGGAAT
AACTACCTCGGCAGCTATAAATATGTTTTTAAAAGCGGCAATTAGAAAAAACACACTACCATTTAGTATTGAGTTAGATA
CACCAAGTAAAGAAACTTTAAAAGCCATAAAAGAAGCTGAAGAACTTTTGAAAGACCCTAATACAAAATATCATTCAAGT
CTTAAAGAATTTTTAAAATCATTAGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C5B7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5BPZ6

References