Detailed information of TA system TA046573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2168159..2169137
• Replicon: chromosome
• Accession: NZ_CP007512
• Organism: Bacillus bombysepticus str. Wang

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: W8Y388
• Locus tag: CY96_RS11055
• Protein ID: WP_000624977.1
• Coordinates: 2168159..2168896 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W8YZL5
• Locus tag: CY96_RS11060
• Protein ID: WP_000237818.1
• Coordinates: 2169009..2169137 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CY96_RS11035	2163802..2164584	+	783	WP_000381800.1	class I SAM-dependent methyltransferase	-
CY96_RS11040	2164742..2166427	-	1686	WP_044584463.1	alpha-keto acid decarboxylase family protein	-
CY96_RS11045	2166535..2167017	+	483	WP_000191888.1	MarR family winged helix-turn-helix transcriptional regulator	-
CY96_RS11050	2167184..2167921	+	738	WP_000594150.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
CY96_RS11055	2168159..2168896	+	738	WP_000624977.1	stage II sporulation protein SA	Toxin
CY96_RS11060	2169009..2169137	+	129	WP_000237818.1	hypothetical protein	Antitoxin
CY96_RS11065	2169210..2169386	+	177	WP_000852629.1	stage II sporulation protein SB	-
CY96_RS11070	2169405..2169794	-	390	WP_000713866.1	YxeA family protein	-
CY96_RS11075	2170006..2171475	+	1470	WP_044584464.1	beta-Ala-His dipeptidase	-
CY96_RS11080	2171721..2172530	+	810	WP_044584465.1	C39 family peptidase	-
CY96_RS11085	2172556..2173158	+	603	WP_000517260.1	hypothetical protein	-
CY96_RS11090	2173399..2173650	-	252	WP_000827561.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28307.03 Da
• Isoelectric Point: 8.2998

>T46573 WP_000624977.1 NZ_CP007512:2168159-2168896 [Bacillus bombysepticus str. Wang]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T46573 NZ_CP007512:2168159-2168896 [Bacillus bombysepticus str. Wang]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCAAAATTTAGCGATATTGGCAAGACAGTTCAATCCATAAAACGATC
ATTAATTGCATCTAAAGCAAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCTGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCACAATTTAGTATTATCGTCCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5011.40 Da
• Isoelectric Point: 3.9150

>AT46573 WP_000237818.1 NZ_CP007512:2169009-2169137 [Bacillus bombysepticus str. Wang]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT46573 NZ_CP007512:2169009-2169137 [Bacillus bombysepticus str. Wang]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Toxin

• AlphaFold DB: W8Y388

Antitoxin

• AlphaFold DB: W8YZL5