46572

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 84760..85402 Replicon chromosome
Accession NZ_CP007512
Organism Bacillus bombysepticus str. Wang

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag CY96_RS00450 Protein ID WP_000635965.1
Coordinates 85052..85402 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag CY96_RS00445 Protein ID WP_000004570.1
Coordinates 84760..85047 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CY96_RS00420 80077..81039 + 963 WP_000961161.1 UV DNA damage repair endonuclease UvsE -
CY96_RS00425 81032..81604 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
CY96_RS00430 81698..82057 + 360 WP_000583417.1 holo-ACP synthase -
CY96_RS00435 82214..83164 + 951 WP_002004297.1 outer membrane lipoprotein carrier protein LolA -
CY96_RS00440 83282..84451 + 1170 WP_000390617.1 alanine racemase -
CY96_RS00445 84760..85047 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
CY96_RS00450 85052..85402 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CY96_RS00455 85470..87638 + 2169 WP_000426241.1 RNA-binding transcriptional accessory protein -
CY96_RS00460 87696..87812 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
CY96_RS00465 88007..88465 + 459 WP_000344241.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T46572 WP_000635965.1 NZ_CP007512:85052-85402 [Bacillus bombysepticus str. Wang]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T46572 NZ_CP007512:85052-85402 [Bacillus bombysepticus str. Wang]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTATGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT46572 WP_000004570.1 NZ_CP007512:84760-85047 [Bacillus bombysepticus str. Wang]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT46572 NZ_CP007512:84760-85047 [Bacillus bombysepticus str. Wang]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References