Detailed information of TA system TA046569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 11695..12220
• Replicon: plasmid unnamed
• Accession: NZ_CP007508
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Durban

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: CS37_RS22730
• Protein ID: WP_001159863.1
• Coordinates: 11695..12000 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: CS37_RS22735
• Protein ID: WP_000813641.1
• Coordinates: 12002..12220 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS37_RS22690	7074..7634	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
CS37_RS25375	7790..8077	+	288	WP_071530243.1	hypothetical protein	-
CS37_RS22700	8354..8839	-	486	WP_000905606.1	membrane protein	-
CS37_RS22705	8833..9342	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
CS37_RS22710	9346..10059	-	714	WP_000545756.1	EAL domain-containing protein	-
CS37_RS22715	10068..10850	-	783	WP_000082169.1	site-specific integrase	-
CS37_RS22720	10885..11406	-	522	WP_000198608.1	hypothetical protein	-
CS37_RS22725	11403..11693	-	291	WP_025375060.1	hypothetical protein	-
CS37_RS22730	11695..12000	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
CS37_RS22735	12002..12220	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CS37_RS22740	12896..13417	+	522	WP_077681952.1	hypothetical protein	-
CS37_RS25380	13461..13889	-	429	Protein_20	hypothetical protein	-
CS37_RS24975	13901..14196	+	296	Protein_21	cytoplasmic protein	-
CS37_RS22755	14690..15679	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
CS37_RS24465	16006..16167	-	162	WP_015059604.1	hypothetical protein	-
CS37_RS22760	16220..16606	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59372	59372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T46569 WP_001159863.1 NZ_CP007508:c12000-11695 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T46569 NZ_CP007508:c12000-11695 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT46569 WP_000813641.1 NZ_CP007508:c12220-12002 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT46569 NZ_CP007508:c12220-12002 [Salmonella enterica subsp. enterica serovar Enteritidis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6