Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1248736..1250602 Replicon chromosome
Accession NZ_CP007506
Organism Pandoraea pnomenusa strain RB38

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DA70_RS05590 Protein ID WP_029754275.1
Coordinates 1248736..1249662 (+) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DA70_RS05595 Protein ID WP_162835271.1
Coordinates 1249664..1250602 (+) Length 313 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA70_RS05565 1244068..1245144 + 1077 WP_023873350.1 porin -
DA70_RS05570 1245554..1246339 + 786 WP_029754279.1 ABC transporter ATP-binding protein -
DA70_RS05575 1246380..1247162 + 783 WP_023597214.1 ABC transporter permease -
DA70_RS05580 1247179..1247970 + 792 WP_023597213.1 SDR family oxidoreductase -
DA70_RS05585 1248029..1248586 + 558 WP_023597212.1 cupin domain-containing protein -
DA70_RS05590 1248736..1249662 + 927 WP_029754275.1 alpha/beta fold hydrolase Toxin
DA70_RS05595 1249664..1250602 + 939 WP_162835271.1 IclR family transcriptional regulator Antitoxin
DA70_RS05600 1250599..1251405 + 807 WP_023597209.1 SDR family oxidoreductase -
DA70_RS05605 1251398..1253050 + 1653 WP_023873356.1 thiamine pyrophosphate-binding protein -
DA70_RS05610 1253043..1253861 + 819 WP_025249664.1 aspartate dehydrogenase -
DA70_RS05615 1253875..1255371 + 1497 WP_023597206.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(59-291)

Antitoxin

Transcription regulator IclR, C-terminal

(167-290)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31559.68 Da        Isoelectric Point: 6.2299

>T46567 WP_029754275.1 NZ_CP007506:1248736-1249662 [Pandoraea pnomenusa]
MQAQANSSEVSEVSADADVPDVAALRARLAAFPYRTVATRAGTVGYRCATAQAADAVPVVMLHGIGSGAASWLAQFEATG
LGASLYAWDAPGYGQTTNVAPAEPDADAYADALEAWLDALGLARVALAGHSLGAIMASRFAARAPHRVLGLFLCSPAGGY
GKADPAVRAAKRDSRLAMLHKLGPAGMARERSDNLVAPNAADLPRAWVKWNMSRVRPEGYAQATHLLSNGDVAGDLARYT
AAKAGPVAVAVGAQDAVTPPASCQTIADVAGVPLQIIEGAGHASYIETPDVLDAALAAWLGRIAAGER

Download         Length: 927 bp

>T46567 NZ_CP007506:1248736-1249662 [Pandoraea pnomenusa]
ATGCAAGCCCAAGCCAACTCGTCCGAAGTGTCCGAAGTGTCCGCAGACGCCGATGTCCCCGATGTCGCCGCCCTGCGCGC
GCGCCTGGCGGCCTTCCCGTATCGCACCGTCGCCACGCGCGCGGGGACCGTCGGCTATCGCTGCGCGACGGCGCAAGCCG
CTGATGCCGTCCCTGTGGTGATGCTGCACGGCATCGGGTCGGGGGCGGCGTCGTGGCTGGCGCAGTTCGAAGCGACGGGC
CTTGGCGCCTCGCTTTATGCCTGGGATGCCCCTGGCTACGGTCAGACAACGAATGTCGCGCCTGCCGAGCCGGATGCCGA
CGCCTACGCCGACGCCCTCGAAGCGTGGCTTGATGCGCTCGGTCTTGCGCGCGTGGCGCTGGCCGGCCATTCGCTCGGCG
CGATCATGGCGTCGAGGTTTGCCGCGCGTGCGCCGCACCGCGTGCTCGGCCTGTTTCTGTGCTCGCCGGCAGGGGGCTAC
GGCAAGGCCGACCCGGCAGTACGGGCGGCCAAGCGCGACAGCCGCCTGGCGATGCTTCACAAACTCGGTCCCGCGGGCAT
GGCGCGCGAACGCAGCGACAACCTCGTGGCACCGAACGCGGCCGACCTGCCGCGCGCCTGGGTGAAGTGGAACATGTCGC
GGGTGCGGCCCGAGGGCTACGCGCAGGCGACCCATCTGCTCTCGAACGGCGATGTGGCGGGCGACCTGGCCCGGTACACG
GCGGCCAAGGCCGGCCCCGTCGCGGTGGCCGTCGGCGCCCAGGATGCCGTCACCCCTCCCGCGAGCTGCCAGACGATTGC
CGACGTCGCCGGTGTGCCGCTTCAGATTATCGAAGGGGCCGGCCACGCGTCTTACATTGAAACGCCCGACGTGCTCGATG
CCGCGCTTGCCGCGTGGCTTGGGCGCATTGCGGCAGGGGAGCGTTGA

Antitoxin


Download         Length: 313 a.a.        Molecular weight: 33953.70 Da        Isoelectric Point: 6.0582

>AT46567 WP_162835271.1 NZ_CP007506:1249664-1250602 [Pandoraea pnomenusa]
MAPANPKRAVAAASIDDSTQDVQDMQDTLDDEVAEAAPAESRYLVPGLERGLRILTQFSPRESVFSAPELSQRLGIPRTT
VFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSV
AGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFERG
ISVVSAPVRNDAGRICAAITVTIPRANIDSAMLDAGLIGQVREAADALSHRLNYRPGGDGRTSPYMKSLGLK

Download         Length: 939 bp

>AT46567 NZ_CP007506:1249664-1250602 [Pandoraea pnomenusa]
ATGGCACCCGCCAATCCGAAGCGCGCCGTCGCCGCGGCGTCGATCGACGACAGCACGCAGGACGTACAGGACATGCAGGA
CACGCTGGACGACGAAGTCGCCGAGGCGGCGCCCGCCGAATCGCGTTACCTCGTGCCGGGGCTGGAGCGCGGCCTGCGCA
TCCTGACGCAATTCTCGCCGCGCGAGTCGGTCTTCAGCGCACCGGAGCTCTCGCAGCGCCTCGGTATTCCGCGCACGACG
GTCTTCCGTTTGCTGCAAACGCTTGAGGCGATGGGCTTTCTCGAGCGCGCGGGCAGCGAAAAGAACTTCCGTCTGGGCGT
GGCGGTGCTGCGTCTGGGCTTCGAATACCTGAGCTCGCTGGAGCTCACCGATCTGGGCATTCCCATCATCGAGCGGCTGC
GCGATGCCACCCAGCTGACGTCGCACATCGTGATTCGCGACGGGCGCGACATCGTGTTCGTGGCCAAGGCGCAGAGCGTG
GCCGGGGTGTTCAATTCGATCAAGGTCAACGTCGGTACGCGCTTGCCTGCGCATGCCACGGTCCACGGCCATGTGCTGAT
GGGCGATCTCACGCTCGCCGAACTGCGTGCGCTGTATCCCGAGAAGACGCTGGAGAAATACACGCCGCAGACCCCCGAGA
CGCTCGCCGAGTTGTTCGAGCGCGTGCGCGAGGACGCCGAACGCGGGTATGCCGTCTCGGCCTCGTCCTTCGAGCGCGGC
ATCAGCGTCGTGAGCGCGCCGGTACGCAACGACGCGGGCCGCATCTGCGCCGCGATCACGGTCACGATCCCGCGCGCGAA
CATCGATTCGGCAATGCTCGACGCGGGACTGATCGGGCAGGTGCGCGAAGCCGCCGACGCGCTCTCGCACCGTCTGAATT
ACCGGCCGGGCGGCGACGGCCGCACCTCCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References