Detailed information of TA system TA046565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 1852152..1852654
• Replicon: chromosome
• Accession: NZ_CP007502
• Organism: Aggregatibacter actinomycetemcomitans HK1651

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: CF65_RS08990
• Protein ID: WP_005547296.1
• Coordinates: 1852152..1852403 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JRQ5
• Locus tag: CF65_RS08995
• Protein ID: WP_025298489.1
• Coordinates: 1852400..1852654 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CF65_RS08970	1847458..1848651	-	1194	WP_005556328.1	hypothetical protein	-
CF65_RS08975	1848660..1849433	-	774	WP_025298488.1	glycosyltransferase family 25 protein	-
CF65_RS08980	1849567..1851090	+	1524	WP_005567290.1	polysaccharide biosynthesis protein	-
CF65_RS08985	1851087..1852043	+	957	WP_005556319.1	polysaccharide pyruvyl transferase family protein	-
CF65_RS08990	1852152..1852403	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
CF65_RS08995	1852400..1852654	+	255	WP_025298489.1	Txe/YoeB family addiction module toxin	Antitoxin
CF65_RS09000	1852667..1853410	+	744	WP_025298490.1	YdcF family protein	-
CF65_RS09005	1853587..1854414	+	828	WP_005556311.1	DNA ligase	-
CF65_RS09010	1854547..1856721	-	2175	WP_005556309.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T46565 WP_005547296.1 NZ_CP007502:1852152-1852403 [Aggregatibacter actinomycetemcomitans HK1651]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T46565 NZ_CP007502:1852152-1852403 [Aggregatibacter actinomycetemcomitans HK1651]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10216.77 Da
• Isoelectric Point: 9.7542

>AT46565 WP_025298489.1 NZ_CP007502:1852400-1852654 [Aggregatibacter actinomycetemcomitans HK1651]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPKPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT46565 NZ_CP007502:1852400-1852654 [Aggregatibacter actinomycetemcomitans HK1651]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTAAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: X2JRQ5