Detailed information of TA system TA046563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1290263..1290813
• Replicon: chromosome
• Accession: NZ_CP007502
• Organism: Aggregatibacter actinomycetemcomitans HK1651

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: CF65_RS06445
• Protein ID: WP_005545988.1
• Coordinates: 1290263..1290529 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: CF65_RS06450
• Protein ID: WP_005539223.1
• Coordinates: 1290541..1290813 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CF65_RS06415	1285443..1286351	-	909	WP_025298347.1	hypothetical protein	-
CF65_RS06420	1286442..1287107	-	666	WP_005567468.1	helix-turn-helix domain-containing protein	-
CF65_RS06425	1287208..1287447	+	240	WP_005567469.1	hypothetical protein	-
CF65_RS06430	1287474..1287665	+	192	Protein_1260	phage head protein	-
CF65_RS06435	1287931..1288347	+	417	WP_025298349.1	hypothetical protein	-
CF65_RS10550	1288347..1288466	-	120	Protein_1262	DUF4102 domain-containing protein	-
CF65_RS06440	1288672..1290231	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
CF65_RS06445	1290263..1290529	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CF65_RS06450	1290541..1290813	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CF65_RS06455	1291068..1292420	-	1353	WP_025298350.1	anaerobic C4-dicarboxylate transporter DcuC	-
CF65_RS06465	1292859..1293314	+	456	WP_005545995.1	ribosome maturation factor RimP	-
CF65_RS06470	1293338..1294834	+	1497	WP_005567486.1	transcription termination/antitermination protein NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T46563 WP_005545988.1 NZ_CP007502:c1290529-1290263 [Aggregatibacter actinomycetemcomitans HK1651]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T46563 NZ_CP007502:c1290529-1290263 [Aggregatibacter actinomycetemcomitans HK1651]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT46563 WP_005539223.1 NZ_CP007502:c1290813-1290541 [Aggregatibacter actinomycetemcomitans HK1651]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT46563 NZ_CP007502:c1290813-1290541 [Aggregatibacter actinomycetemcomitans HK1651]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Structures

Toxin

• AlphaFold DB: X2JVL6

Antitoxin

• AlphaFold DB: X2JQ67