Detailed information of TA system TA046542

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 913452..913984
• Replicon: chromosome
• Accession: NZ_CP007499
• Organism: Staphylococcus aureus strain 2395 USA500

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CH51_RS04535
• Protein ID: WP_001103942.1
• Coordinates: 913664..913984 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CH51_RS04530
• Protein ID: WP_001058486.1
• Coordinates: 913452..913661 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH51_RS04485	908471..909691	-	1221	WP_000266157.1	site-specific integrase	-
CH51_RS04490	909780..910508	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
CH51_RS04495	910532..911260	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
CH51_RS04500	911330..911761	-	432	WP_001228759.1	hypothetical protein	-
CH51_RS04505	911778..912236	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CH51_RS04510	912248..912580	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CH51_RS04515	912773..913036	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
CH51_RS04520	913029..913301	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CH51_RS04525	913313..913459	+	147	WP_000784875.1	hypothetical protein	-
CH51_RS04530	913452..913661	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CH51_RS04535	913664..913984	+	321	WP_001103942.1	DUF1474 family protein	Toxin
CH51_RS04540	914048..914917	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CH51_RS04545	914934..916391	+	1458	WP_000390455.1	virulence-associated E family protein	-
CH51_RS04550	916692..917054	+	363	WP_001039168.1	hypothetical protein	-
CH51_RS04555	917056..917340	+	285	WP_000998181.1	hypothetical protein	-
CH51_RS04560	917337..917978	+	642	WP_001019764.1	hypothetical protein	-
CH51_RS04565	918495..918836	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	clpP / vWbp / selk / selq / seb	864189..923786	59597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T46542 WP_001103942.1 NZ_CP007499:913664-913984 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T46542 NZ_CP007499:913664-913984 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT46542 WP_001058486.1 NZ_CP007499:913452-913661 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT46542 NZ_CP007499:913452-913661 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4