Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 895838..896315 Replicon chromosome
Accession NZ_CP007499
Organism Staphylococcus aureus strain 2395 USA500

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CH51_RS04380 Protein ID WP_000052078.1
Coordinates 895838..896026 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CH51_RS04385 Protein ID WP_001059690.1
Coordinates 896055..896315 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH51_RS04350 891879..892349 + 471 WP_000824472.1 hypothetical protein -
CH51_RS04355 892690..893376 + 687 WP_001548082.1 thermonuclease family protein -
CH51_RS04360 893733..893933 + 201 WP_001059082.1 cold-shock protein -
CH51_RS04365 894429..894647 - 219 WP_000005886.1 hypothetical protein -
CH51_RS04370 894709..894993 - 285 WP_001004395.1 hypothetical protein -
CH51_RS04375 895081..895650 - 570 WP_001106654.1 hypothetical protein -
CH51_RS04380 895838..896026 - 189 WP_000052078.1 hypothetical protein Toxin
CH51_RS04385 896055..896315 - 261 WP_001059690.1 hypothetical protein Antitoxin
CH51_RS04390 896656..896859 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CH51_RS04395 896856..897092 - 237 WP_000368687.1 hypothetical protein -
CH51_RS04400 897317..897898 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
CH51_RS04405 897971..898588 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CH51_RS04410 898743..899237 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CH51_RS04415 899636..900058 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CH51_RS04420 900206..900922 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - clpP / vWbp / selk / selq / seb 864189..923786 59597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46541 WP_000052078.1 NZ_CP007499:c896026-895838 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46541 NZ_CP007499:c896026-895838 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46541 WP_001059690.1 NZ_CP007499:c896315-896055 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46541 NZ_CP007499:c896315-896055 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References