46537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1437778..1438261 Replicon chromosome
Accession NZ_CP007497
Organism Streptococcus suis strain ZY05719 isolate diseased pig

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag ZY05719_RS07085 Protein ID WP_012027435.1
Coordinates 1437778..1438038 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag ZY05719_RS07090 Protein ID WP_012775256.1
Coordinates 1438040..1438261 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZY05719_RS07060 (ZY05719_07090) 1433162..1434391 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
ZY05719_RS07065 (ZY05719_07095) 1434415..1435548 - 1134 WP_046735930.1 AI-2E family transporter -
ZY05719_RS07070 (ZY05719_07100) 1435684..1436688 + 1005 WP_012028380.1 lactonase family protein -
ZY05719_RS07075 (ZY05719_07105) 1436752..1436937 + 186 WP_002935693.1 hypothetical protein -
ZY05719_RS07080 (ZY05719_07110) 1436970..1437611 - 642 WP_012775255.1 HAD family hydrolase -
ZY05719_RS07085 (ZY05719_07115) 1437778..1438038 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ZY05719_RS07090 (ZY05719_07120) 1438040..1438261 - 222 WP_012775256.1 hypothetical protein Antitoxin
ZY05719_RS07095 (ZY05719_07125) 1438571..1439878 - 1308 WP_002935704.1 phosphopyruvate hydratase -
ZY05719_RS07100 (ZY05719_07130) 1440028..1440480 + 453 WP_012028381.1 DUF1694 domain-containing protein -
ZY05719_RS10610 1440487..1440716 - 230 Protein_1343 hypothetical protein -
ZY05719_RS07105 (ZY05719_07140) 1440707..1441834 - 1128 WP_012028382.1 glycerate kinase -
ZY05719_RS07110 (ZY05719_07145) 1441942..1442592 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T46537 WP_012027435.1 NZ_CP007497:c1438038-1437778 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T46537 NZ_CP007497:c1438038-1437778 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT46537 WP_012775256.1 NZ_CP007497:c1438261-1438040 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT46537 NZ_CP007497:c1438261-1438040 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References