Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 859833..860470 Replicon chromosome
Accession NZ_CP007493
Organism Thermofilum adornatum 1505

Toxin (Protein)


Gene name vapC Uniprot ID A0A3G1A5D7
Locus tag TCARB_RS04580 Protein ID WP_052886871.1
Coordinates 860057..860470 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID S5ZXS8
Locus tag TCARB_RS04575 Protein ID WP_020963501.1
Coordinates 859833..860057 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TCARB_RS04560 (TCARB_0965) 855397..856746 - 1350 WP_052886868.1 NADP-dependent malic enzyme -
TCARB_RS04565 (TCARB_0966) 857017..858315 - 1299 WP_052886869.1 acetamidase/formamidase family protein -
TCARB_RS04570 (TCARB_0967) 858580..859443 - 864 WP_052886870.1 ATP-dependent Clp protease proteolytic subunit -
TCARB_RS04575 (TCARB_0968) 859833..860057 + 225 WP_020963501.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
TCARB_RS04580 (TCARB_0969) 860057..860470 + 414 WP_052886871.1 type II toxin-antitoxin system VapC family toxin Toxin
TCARB_RS04585 (TCARB_0971) 860715..861080 - 366 WP_052886872.1 nucleotidyltransferase domain-containing protein -
TCARB_RS04590 (TCARB_0972) 861067..861264 - 198 WP_052886873.1 HEPN domain-containing protein -
TCARB_RS04595 (TCARB_0973) 861423..862256 + 834 WP_052886874.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
TCARB_RS04600 (TCARB_0974) 862243..862782 + 540 WP_052886875.1 hypothetical protein -
TCARB_RS04605 (TCARB_0975) 862788..864350 - 1563 WP_148684625.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 846467..865954 19487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(6-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15775.49 Da        Isoelectric Point: 5.0589

>T46531 WP_052886871.1 NZ_CP007493:860057-860470 [Thermofilum adornatum 1505]
MVEYLLDASALYPLMLKMKDKLFDYLNLFVVLDLTVYEIGNVIWKESRVGRVRAPKALAIAFAEVFRGVKVVRLRDEEIA
DVLELALAEEITFYDAAYLYAARKLRLRLVTEDSDLKKYPESVGLEELVAGLERSRR

Download         Length: 414 bp

>T46531 NZ_CP007493:860057-860470 [Thermofilum adornatum 1505]
ATGGTTGAGTACCTGCTTGACGCCTCTGCACTTTATCCACTCATGTTGAAGATGAAGGATAAGCTTTTCGACTACTTAAA
TCTCTTTGTAGTGCTGGATCTGACAGTATATGAGATTGGCAACGTGATTTGGAAGGAGAGTCGGGTAGGCAGGGTTAGGG
CTCCTAAGGCTTTAGCGATAGCATTCGCAGAGGTATTTAGGGGAGTTAAGGTTGTCAGATTGAGGGACGAGGAAATAGCG
GACGTCTTAGAGCTGGCTTTGGCGGAGGAAATAACCTTCTATGATGCGGCTTACCTGTACGCAGCTAGAAAGCTCCGCTT
AAGGCTTGTGACCGAGGACTCGGATTTGAAAAAGTACCCAGAATCTGTAGGCTTAGAAGAGCTCGTTGCAGGGCTAGAGC
GTTCGAGGCGTTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8773.12 Da        Isoelectric Point: 6.9899

>AT46531 WP_020963501.1 NZ_CP007493:859833-860057 [Thermofilum adornatum 1505]
VSTEVLSVRVRRELKEEALRLGIDVRSVIERALEEEVRKAKKEKFRELLEEALKGCDITVEEWVRAVKETRREH

Download         Length: 225 bp

>AT46531 NZ_CP007493:859833-860057 [Thermofilum adornatum 1505]
GTGTCTACTGAAGTGCTATCTGTTAGGGTCAGGAGAGAGCTTAAGGAGGAAGCTTTGAGGCTGGGAATCGATGTTAGGAG
TGTTATTGAGAGGGCTCTCGAGGAGGAGGTAAGAAAGGCGAAGAAGGAGAAGTTCAGGGAGTTGCTCGAGGAAGCCCTAA
AGGGTTGCGACATAACGGTTGAAGAATGGGTTAGGGCAGTAAAGGAAACTAGGAGGGAACATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G1A5D7

Antitoxin

Source ID Structure
AlphaFold DB S5ZXS8

References