Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 758201..758840 Replicon chromosome
Accession NZ_CP007493
Organism Thermofilum adornatum 1505

Toxin (Protein)


Gene name vapC Uniprot ID A0A3G1A572
Locus tag TCARB_RS04020 Protein ID WP_052886784.1
Coordinates 758201..758617 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3G1A6S6
Locus tag TCARB_RS04025 Protein ID WP_052886785.1
Coordinates 758598..758840 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TCARB_RS04000 (TCARB_0845) 753968..754768 - 801 WP_052886782.1 hypothetical protein -
TCARB_RS04005 (TCARB_0847) 754793..756070 - 1278 WP_020963412.1 APC family permease -
TCARB_RS04010 (TCARB_0848) 756218..756604 + 387 WP_020963413.1 hypothetical protein -
TCARB_RS04015 (TCARB_0849) 756652..758022 + 1371 WP_052886783.1 alpha-glucosidase/alpha-galactosidase -
TCARB_RS04020 (TCARB_0850) 758201..758617 - 417 WP_052886784.1 PIN domain-containing protein Toxin
TCARB_RS04025 (TCARB_0851) 758598..758840 - 243 WP_052886785.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
TCARB_RS04030 (TCARB_0852) 759241..759603 - 363 WP_052886786.1 hypothetical protein -
TCARB_RS04035 (TCARB_0853) 759705..760583 + 879 WP_052886787.1 winged helix-turn-helix domain-containing protein -
TCARB_RS04040 (TCARB_0854) 760713..761267 + 555 WP_052886788.1 hypothetical protein -
TCARB_RS04045 (TCARB_0855) 761337..762533 + 1197 WP_052886789.1 hypothetical protein -
TCARB_RS04050 762490..762789 + 300 WP_148684601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(3-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15781.21 Da        Isoelectric Point: 4.7943

>T46530 WP_052886784.1 NZ_CP007493:c758617-758201 [Thermofilum adornatum 1505]
MPEAVIDTNILIYDTFEDSLYHKEASHILDSLNRWIIPLIVIYEYAWFLKGLKMSTADARDKVLEYITSEKSVLVREGLD
EIRWAISTLVDEGLSLSRFNDKVVLSVALRRNVPLATFDEKLRRQASNIGVALVPETL

Download         Length: 417 bp

>T46530 NZ_CP007493:c758617-758201 [Thermofilum adornatum 1505]
TTGCCGGAGGCGGTGATTGACACAAATATCCTTATCTACGATACCTTTGAGGATTCTCTCTACCACAAGGAGGCTTCCCA
TATACTTGACAGTTTAAACCGGTGGATAATTCCCCTAATAGTCATCTACGAGTATGCTTGGTTCCTGAAGGGGTTAAAAA
TGAGTACAGCTGATGCTCGGGACAAGGTACTCGAGTATATTACCTCCGAGAAGTCCGTATTGGTGAGGGAGGGCTTAGAT
GAGATCCGCTGGGCTATCTCCACACTTGTAGATGAGGGCCTGTCTCTCTCACGCTTCAATGACAAAGTCGTGCTTTCAGT
AGCTCTGCGAAGAAATGTTCCACTAGCGACCTTCGATGAAAAGCTGAGGAGGCAAGCATCCAATATAGGTGTGGCATTAG
TTCCCGAGACATTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8957.46 Da        Isoelectric Point: 10.2561

>AT46530 WP_052886785.1 NZ_CP007493:c758840-758598 [Thermofilum adornatum 1505]
VKRSKITRSFQVTIPKEIREALGLQIGDYLDMYVDEKGRIIMEKKVLRRKTFRAGRPLTPEEIDGIIAKGLGENIAGGGD

Download         Length: 243 bp

>AT46530 NZ_CP007493:c758840-758598 [Thermofilum adornatum 1505]
GTGAAGAGAAGTAAAATAACGAGAAGTTTTCAAGTAACGATTCCAAAAGAGATACGTGAGGCATTGGGACTGCAGATCGG
CGACTACCTGGACATGTATGTGGATGAAAAGGGGAGAATCATTATGGAGAAAAAAGTTCTGAGGAGGAAGACTTTTAGAG
CTGGAAGACCCCTTACTCCGGAAGAAATTGACGGGATAATCGCTAAAGGGCTGGGTGAAAACATTGCCGGAGGCGGTGAT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G1A572

Antitoxin

Source ID Structure
AlphaFold DB A0A3G1A6S6

References