46529

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4774410..4775230 Replicon chromosome
Accession NZ_CP007491
Organism Escherichia coli strain ACN002

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag ACN002_RS23640 Protein ID WP_001054379.1
Coordinates 4774973..4775230 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag ACN002_RS23635 Protein ID WP_000123957.1
Coordinates 4774410..4774961 (-) Length 184 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACN002_RS23610 4770104..4771417 - 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -
ACN002_RS23615 4771429..4771707 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ACN002_RS23620 4771704..4772825 - 1122 WP_000010833.1 M42 family metallopeptidase -
ACN002_RS27260 4773070..4773186 - 117 Protein_4486 VOC family protein -
ACN002_RS23625 4773224..4773484 - 261 WP_000077646.1 hypothetical protein -
ACN002_RS23630 4773612..4774358 - 747 WP_001588380.1 class I SAM-dependent methyltransferase -
ACN002_RS23635 4774410..4774961 - 552 WP_000123957.1 N-acetyltransferase Antitoxin
ACN002_RS23640 4774973..4775230 - 258 WP_001054379.1 YjhX family toxin Toxin
ACN002_RS23645 4775607..4775906 - 300 WP_001332034.1 GNAT family N-acetyltransferase -
ACN002_RS23650 4775984..4777210 + 1227 Protein_4492 helicase YjhR -
ACN002_RS23655 4777793..4778773 - 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ACN002_RS23660 4778837..4779943 - 1107 WP_001295733.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(19-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T46529 WP_001054379.1 NZ_CP007491:c4775230-4774973 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T46529 NZ_CP007491:c4775230-4774973 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT46529 WP_000123957.1 NZ_CP007491:c4774961-4774410 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp

>AT46529 NZ_CP007491:c4774961-4774410 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B6I030


Antitoxin

Source ID Structure

References