Detailed information of TA system TA046529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4774410..4775230
• Replicon: chromosome
• Accession: NZ_CP007491
• Organism: Escherichia coli strain ACN002

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: ACN002_RS23640
• Protein ID: WP_001054379.1
• Coordinates: 4774973..4775230 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: ACN002_RS23635
• Protein ID: WP_000123957.1
• Coordinates: 4774410..4774961 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACN002_RS23610	4770104..4771417	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
ACN002_RS23615	4771429..4771707	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
ACN002_RS23620	4771704..4772825	-	1122	WP_000010833.1	M42 family metallopeptidase	-
ACN002_RS27260	4773070..4773186	-	117	Protein_4486	VOC family protein	-
ACN002_RS23625	4773224..4773484	-	261	WP_000077646.1	hypothetical protein	-
ACN002_RS23630	4773612..4774358	-	747	WP_001588380.1	class I SAM-dependent methyltransferase	-
ACN002_RS23635	4774410..4774961	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
ACN002_RS23640	4774973..4775230	-	258	WP_001054379.1	YjhX family toxin	Toxin
ACN002_RS23645	4775607..4775906	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
ACN002_RS23650	4775984..4777210	+	1227	Protein_4492	helicase YjhR	-
ACN002_RS23655	4777793..4778773	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
ACN002_RS23660	4778837..4779943	-	1107	WP_001295733.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T46529 WP_001054379.1 NZ_CP007491:c4775230-4774973 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T46529 NZ_CP007491:c4775230-4774973 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT46529 WP_000123957.1 NZ_CP007491:c4774961-4774410 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT46529 NZ_CP007491:c4774961-4774410 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030