Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1245841..1246319 Replicon chromosome
Accession NZ_CP007472
Organism Haemophilus influenzae strain 723

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag NTHI723_RS06165 Protein ID WP_044364768.1
Coordinates 1246041..1246319 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag NTHI723_RS06160 Protein ID WP_011272059.1
Coordinates 1245841..1246032 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI723_RS06135 1241420..1242052 + 633 WP_044365145.1 dTMP kinase -
NTHI723_RS06140 1242049..1243032 + 984 WP_044364765.1 DNA polymerase III subunit delta' -
NTHI723_RS06145 1243087..1243869 + 783 WP_011272061.1 YchF/TatD family DNA exonuclease -
NTHI723_RS06150 1243896..1244420 + 525 WP_011272060.1 DUF1523 family protein -
NTHI723_RS06155 1244471..1245769 + 1299 WP_005691371.1 hemolysin family protein -
NTHI723_RS06160 1245841..1246032 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
NTHI723_RS06165 1246041..1246319 + 279 WP_044364768.1 virulence-associated protein VapD Toxin
NTHI723_RS06170 1246412..1246942 + 531 WP_005649345.1 hypothetical protein -
NTHI723_RS06175 1247014..1248513 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
NTHI723_RS06180 1248515..1249456 + 942 WP_011272055.1 1-phosphofructokinase -
NTHI723_RS06185 1249458..1251128 + 1671 WP_011272054.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10598.99 Da        Isoelectric Point: 4.6712

>T46504 WP_044364768.1 NZ_CP007472:1246041-1246319 [Haemophilus influenzae]
MYAIAFDLVVKDTQDDHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T46504 NZ_CP007472:1246041-1246319 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATGATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT46504 WP_011272059.1 NZ_CP007472:1245841-1246032 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp

>AT46504 NZ_CP007472:1245841-1246032 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References