Detailed information of TA system TA046502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 999199..999803
• Replicon: chromosome
• Accession: NZ_CP007472
• Organism: Haemophilus influenzae strain 723

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NTHI723_RS04910
• Protein ID: WP_044364610.1
• Coordinates: 999199..999507 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Y7JSS2
• Locus tag: NTHI723_RS04915
• Protein ID: WP_005661259.1
• Coordinates: 999507..999803 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHI723_RS04905	995828..999142	+	3315	WP_154231780.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
NTHI723_RS04910	999199..999507	-	309	WP_044364610.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
NTHI723_RS04915	999507..999803	-	297	WP_005661259.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
NTHI723_RS04920	999923..1000777	-	855	WP_038440397.1	DUF3298 domain-containing protein	-
NTHI723_RS04925	1000796..1002655	-	1860	WP_044364613.1	selenocysteine-specific translation elongation factor	-
NTHI723_RS04930	1002652..1004037	-	1386	WP_038440401.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-99)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11956.71 Da
• Isoelectric Point: 7.2386

>T46502 WP_044364610.1 NZ_CP007472:c999507-999199 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCYIQGDLVLIYQYV
IHDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T46502 NZ_CP007472:c999507-999199 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCTATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACACGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.37 Da
• Isoelectric Point: 4.4297

>AT46502 WP_005661259.1 NZ_CP007472:c999803-999507 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT46502 NZ_CP007472:c999803-999507 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Y7JSS2