Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 402193..402782 Replicon chromosome
Accession NZ_CP007472
Organism Haemophilus influenzae strain 723

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag NTHI723_RS01935 Protein ID WP_005653200.1
Coordinates 402534..402782 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag NTHI723_RS01930 Protein ID WP_005653201.1
Coordinates 402193..402537 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI723_RS01915 397416..398810 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
NTHI723_RS01920 398854..399468 + 615 WP_005657019.1 riboflavin synthase -
NTHI723_RS01925 399540..402149 - 2610 WP_044364349.1 aminopeptidase N -
NTHI723_RS01930 402193..402537 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NTHI723_RS01935 402534..402782 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
NTHI723_RS01940 402953..403447 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
NTHI723_RS01945 403517..404605 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
NTHI723_RS01950 404745..405935 + 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
NTHI723_RS01955 406042..406668 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
NTHI723_RS01960 406670..407302 - 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T46500 WP_005653200.1 NZ_CP007472:c402782-402534 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T46500 NZ_CP007472:c402782-402534 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT46500 WP_005653201.1 NZ_CP007472:c402537-402193 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT46500 NZ_CP007472:c402537-402193 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References