Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 1541100..1541689 Replicon chromosome
Accession NZ_CP007471
Organism Haemophilus influenzae strain C486

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag NTHIC486_RS07430 Protein ID WP_005653200.1
Coordinates 1541441..1541689 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag NTHIC486_RS07425 Protein ID WP_005653201.1
Coordinates 1541100..1541444 (-) Length 115 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHIC486_RS07410 1536323..1537717 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
NTHIC486_RS07415 1537761..1538375 + 615 WP_005657019.1 riboflavin synthase -
NTHIC486_RS07420 1538447..1541056 - 2610 WP_012054428.1 aminopeptidase N -
NTHIC486_RS07425 1541100..1541444 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NTHIC486_RS07430 1541441..1541689 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
NTHIC486_RS07435 1541860..1542354 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
NTHIC486_RS07440 1542424..1543512 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
NTHIC486_RS07445 1543652..1544842 + 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
NTHIC486_RS07450 1544949..1545575 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
NTHIC486_RS07455 1545577..1546209 - 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-81)

Antitoxin

(54-102)


Sequences


Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T46499 WP_005653200.1 NZ_CP007471:c1541689-1541441 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T46499 NZ_CP007471:c1541689-1541441 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT46499 WP_005653201.1 NZ_CP007471:c1541444-1541100 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT46499 NZ_CP007471:c1541444-1541100 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03


Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References