Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 657877..658514 Replicon chromosome
Accession NZ_CP007471
Organism Haemophilus influenzae strain C486

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A121YHB9
Locus tag NTHIC486_RS03335 Protein ID WP_021035685.1
Coordinates 657877..658281 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag NTHIC486_RS03340 Protein ID WP_005656316.1
Coordinates 658278..658514 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHIC486_RS03305 653439..654005 + 567 WP_005544066.1 elongation factor P -
NTHIC486_RS03315 654357..654941 - 585 WP_044345394.1 primosomal replication protein -
NTHIC486_RS03320 654974..656326 - 1353 WP_021035683.1 Na+/H+ antiporter family protein -
NTHIC486_RS03325 656640..657329 - 690 WP_021035684.1 ribonuclease T -
NTHIC486_RS03330 657403..657810 - 408 WP_005688980.1 lactoylglutathione lyase -
NTHIC486_RS03335 657877..658281 - 405 WP_021035685.1 type II toxin-antitoxin system VapC family toxin Toxin
NTHIC486_RS03340 658278..658514 - 237 WP_005656316.1 antitoxin Antitoxin
NTHIC486_RS03345 658607..659332 - 726 WP_021035687.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
NTHIC486_RS03350 659385..659903 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
NTHIC486_RS03355 660122..661888 + 1767 WP_044345397.1 aspartate--tRNA ligase -
NTHIC486_RS03360 661910..662383 + 474 WP_011271985.1 dihydroneopterin triphosphate diphosphatase -
NTHIC486_RS03365 662395..663135 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15690.26 Da        Isoelectric Point: 8.9777

>T46497 WP_021035685.1 NZ_CP007471:c658281-657877 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T46497 NZ_CP007471:c658281-657877 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTAGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT46497 WP_005656316.1 NZ_CP007471:c658514-658278 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT46497 NZ_CP007471:c658514-658278 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A121YHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References