46496

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 531785..532122 Replicon chromosome
Accession NZ_CP007471
Organism Haemophilus influenzae strain C486

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag NTHIC486_RS02685 Protein ID WP_005686917.1
Coordinates 531985..532122 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag NTHIC486_RS02680 Protein ID WP_005649350.1
Coordinates 531785..531976 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHIC486_RS02655 527364..527996 + 633 WP_005686927.1 dTMP kinase -
NTHIC486_RS02660 527993..528976 + 984 WP_005686925.1 DNA polymerase III subunit delta' -
NTHIC486_RS02665 529031..529813 + 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
NTHIC486_RS02670 529840..530364 + 525 WP_005686921.1 DUF1523 family protein -
NTHIC486_RS02675 530415..531713 + 1299 WP_032821624.1 hemolysin family protein -
NTHIC486_RS02680 531785..531976 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
NTHIC486_RS02685 531985..532122 + 138 WP_005686917.1 hypothetical protein Toxin
NTHIC486_RS02690 532215..532745 + 531 WP_005686915.1 hypothetical protein -
NTHIC486_RS02695 532817..534316 + 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
NTHIC486_RS02700 534318..535259 + 942 WP_005686910.1 1-phosphofructokinase -
NTHIC486_RS02705 535261..536931 + 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T46496 WP_005686917.1 NZ_CP007471:531985-532122 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T46496 NZ_CP007471:531985-532122 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT46496 WP_005649350.1 NZ_CP007471:531785-531976 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT46496 NZ_CP007471:531785-531976 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References