Detailed information of TA system TA046494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 273413..274017
• Replicon: chromosome
• Accession: NZ_CP007471
• Organism: Haemophilus influenzae strain C486

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q4QMK7
• Locus tag: NTHIC486_RS01385
• Protein ID: WP_011272186.1
• Coordinates: 273413..273721 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: NTHIC486_RS01390
• Protein ID: WP_005692346.1
• Coordinates: 273721..274017 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHIC486_RS01375	268581..269879	-	1299	WP_006995277.1	trigger factor	-
NTHIC486_RS01380	270243..273356	+	3114	WP_154231904.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
NTHIC486_RS01385	273413..273721	-	309	WP_011272186.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
NTHIC486_RS01390	273721..274017	-	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
NTHIC486_RS01395	274137..274992	-	856	Protein_274	DUF3298 domain-containing protein	-
NTHIC486_RS01400	275011..276870	-	1860	WP_011272184.1	selenocysteine-specific translation elongation factor	-
NTHIC486_RS01405	276867..278252	-	1386	WP_038440401.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11929.69 Da
• Isoelectric Point: 7.8904

>T46494 WP_011272186.1 NZ_CP007471:c273721-273413 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IHDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T46494 NZ_CP007471:c273721-273413 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACACGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT46494 WP_005692346.1 NZ_CP007471:c274017-273721 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT46494 NZ_CP007471:c274017-273721 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Toxin

• AlphaFold DB: Q4QMK7

Antitoxin

• AlphaFold DB: Q4QMK8