46493

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 51016..51550 Replicon chromosome
Accession NZ_CP007471
Organism Haemophilus influenzae strain C486

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag NTHIC486_RS00290 Protein ID WP_005651512.1
Coordinates 51260..51550 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag NTHIC486_RS00285 Protein ID WP_005651514.1
Coordinates 51016..51270 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHIC486_RS00245 46196..46456 + 261 WP_005663579.1 hypothetical protein -
NTHIC486_RS00250 46486..46851 + 366 WP_005686191.1 endonuclease domain-containing protein -
NTHIC486_RS00255 47189..49255 + 2067 WP_044345139.1 glycine--tRNA ligase subunit beta -
NTHIC486_RS00265 49617..50156 + 540 WP_005659144.1 hypothetical protein -
NTHIC486_RS00270 50186..50494 + 309 WP_005659142.1 P2 family phage major capsid protein -
NTHIC486_RS00275 50494..50718 + 225 WP_005659141.1 hypothetical protein -
NTHIC486_RS00285 51016..51270 + 255 WP_005651514.1 stability protein StbD Antitoxin
NTHIC486_RS00290 51260..51550 + 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NTHIC486_RS08970 51631..51840 + 210 WP_074030365.1 hypothetical protein -
NTHIC486_RS09265 52010..52147 + 138 WP_005659136.1 hypothetical protein -
NTHIC486_RS00295 52624..53658 - 1035 WP_005659128.1 DNA polymerase III subunit delta -
NTHIC486_RS00300 53658..54161 - 504 WP_005659127.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T46493 WP_005651512.1 NZ_CP007471:51260-51550 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T46493 NZ_CP007471:51260-51550 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT46493 WP_005651514.1 NZ_CP007471:51016-51270 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT46493 NZ_CP007471:51016-51270 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References