Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 22043..22674 Replicon chromosome
Accession NZ_CP007471
Organism Haemophilus influenzae strain C486

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag NTHIC486_RS00135 Protein ID WP_005651560.1
Coordinates 22276..22674 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag NTHIC486_RS00130 Protein ID WP_005648011.1
Coordinates 22043..22276 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHIC486_RS00105 17522..18724 - 1203 WP_005686217.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
NTHIC486_RS00110 18888..19553 + 666 WP_032821549.1 DNA repair protein RadC -
NTHIC486_RS00115 19767..20003 + 237 WP_005542826.1 50S ribosomal protein L28 -
NTHIC486_RS00120 20015..20185 + 171 WP_005613503.1 50S ribosomal protein L33 -
NTHIC486_RS00125 20532..21896 + 1365 WP_005664172.1 diaminobutyrate--2-oxoglutarate transaminase -
NTHIC486_RS00130 22043..22276 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
NTHIC486_RS00135 22276..22674 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
NTHIC486_RS00140 22694..24229 + 1536 WP_012054543.1 L-2,4-diaminobutyrate decarboxylase -
NTHIC486_RS00145 24460..25275 + 816 WP_012054544.1 DNA-formamidopyrimidine glycosylase -
NTHIC486_RS00150 25349..26371 - 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
NTHIC486_RS00155 26372..27490 - 1119 WP_005686201.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T46492 WP_005651560.1 NZ_CP007471:22276-22674 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T46492 NZ_CP007471:22276-22674 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT46492 WP_005648011.1 NZ_CP007471:22043-22276 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT46492 NZ_CP007471:22043-22276 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References