Detailed information of TA system TA046490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1777302..1777773
• Replicon: chromosome
• Accession: NZ_CP007470
• Organism: Haemophilus influenzae strain 477

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: NTHI477_RS08740
• Protein ID: WP_005654546.1
• Coordinates: 1777591..1777773 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: NTHI477_RS08735
• Protein ID: WP_005650837.1
• Coordinates: 1777302..1777598 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHI477_RS08710	1772515..1773267	-	753	WP_044333025.1	DUF3800 domain-containing protein	-
NTHI477_RS08715	1773279..1774085	-	807	WP_044333027.1	shikimate dehydrogenase	-
NTHI477_RS08720	1774089..1774640	-	552	WP_044333031.1	Sua5/YciO/YrdC/YwlC family protein	-
NTHI477_RS08725	1774656..1775192	-	537	WP_044333034.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
NTHI477_RS08730	1775202..1777118	-	1917	WP_044333037.1	ABC transporter ATP-binding protein	-
NTHI477_RS08735	1777302..1777598	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
NTHI477_RS08740	1777591..1777773	-	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
NTHI477_RS08745	1778043..1781039	-	2997	WP_044333040.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T46490 WP_005654546.1 NZ_CP007470:c1777773-1777591 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T46490 NZ_CP007470:c1777773-1777591 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT46490 WP_005650837.1 NZ_CP007470:c1777598-1777302 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT46490 NZ_CP007470:c1777598-1777302 [Haemophilus influenzae]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9