Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1411643..1412280 Replicon chromosome
Accession NZ_CP007470
Organism Haemophilus influenzae strain 477

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag NTHI477_RS06765 Protein ID WP_044332440.1
Coordinates 1411876..1412280 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag NTHI477_RS06760 Protein ID WP_044332438.1
Coordinates 1411643..1411879 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI477_RS06735 1407022..1407762 - 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -
NTHI477_RS06740 1407774..1408247 - 474 WP_011271985.1 dihydroneopterin triphosphate diphosphatase -
NTHI477_RS06745 1408269..1410035 - 1767 WP_042594297.1 aspartate--tRNA ligase -
NTHI477_RS06750 1410254..1410772 + 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
NTHI477_RS06755 1410825..1411550 + 726 WP_044332436.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
NTHI477_RS06760 1411643..1411879 + 237 WP_044332438.1 antitoxin Antitoxin
NTHI477_RS06765 1411876..1412280 + 405 WP_044332440.1 type II toxin-antitoxin system VapC family toxin Toxin
NTHI477_RS06770 1412347..1412754 + 408 WP_005628548.1 lactoylglutathione lyase -
NTHI477_RS06775 1412828..1413517 + 690 WP_044332443.1 ribonuclease T -
NTHI477_RS06780 1413831..1415183 + 1353 WP_044332446.1 Na+/H+ antiporter family protein -
NTHI477_RS06785 1415216..1415803 + 588 WP_005654063.1 primosomal replication protein -
NTHI477_RS06795 1416154..1416720 - 567 WP_005544066.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15711.29 Da        Isoelectric Point: 8.9831

>T46488 WP_044332440.1 NZ_CP007470:1411876-1412280 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPQIVAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITRNIKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T46488 NZ_CP007470:1411876-1412280 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCCAAATTGTTGCTGAACGAGTATCACA
ATTATTACCTAACGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGTGCGTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACGTAATATAAAAGAGTTTCAGCGTATTACAGATCTTCAATGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8977.08 Da        Isoelectric Point: 4.2220

>AT46488 WP_044332438.1 NZ_CP007470:1411643-1411879 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPVDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFDGFDESFIQTLEARDDLPPQERENL

Download         Length: 237 bp

>AT46488 NZ_CP007470:1411643-1411879 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTGCGGATCCCAGTGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGAGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTGTTTG
ATGGATTTGATGAAAGTTTTATTCAAACACTTGAAGCCCGTGATGATTTACCGCCTCAAGAACGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References