Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 788026..788657 Replicon chromosome
Accession NZ_CP007470
Organism Haemophilus influenzae strain 477

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag NTHI477_RS03745 Protein ID WP_005651560.1
Coordinates 788259..788657 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag NTHI477_RS03740 Protein ID WP_005648011.1
Coordinates 788026..788259 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI477_RS03715 783506..784708 - 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
NTHI477_RS03720 784871..785536 + 666 WP_013526173.1 DNA repair protein RadC -
NTHI477_RS03725 785750..785986 + 237 WP_005542826.1 50S ribosomal protein L28 -
NTHI477_RS03730 785998..786168 + 171 WP_005613503.1 50S ribosomal protein L33 -
NTHI477_RS03735 786515..787879 + 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
NTHI477_RS03740 788026..788259 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
NTHI477_RS03745 788259..788657 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
NTHI477_RS03750 788677..790212 + 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
NTHI477_RS03755 790444..791259 + 816 WP_011272305.1 DNA-formamidopyrimidine glycosylase -
NTHI477_RS03760 791333..792352 - 1020 WP_044330920.1 outer membrane-stress sensor serine endopeptidase DegS -
NTHI477_RS03765 792353..793471 - 1119 WP_044330922.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T46487 WP_005651560.1 NZ_CP007470:788259-788657 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T46487 NZ_CP007470:788259-788657 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT46487 WP_005648011.1 NZ_CP007470:788026-788259 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT46487 NZ_CP007470:788026-788259 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References