Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 502224..502813 Replicon chromosome
Accession NZ_CP007470
Organism Haemophilus influenzae strain 477

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag NTHI477_RS02370 Protein ID WP_005653200.1
Coordinates 502565..502813 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag NTHI477_RS02365 Protein ID WP_005653201.1
Coordinates 502224..502568 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI477_RS02350 497447..498841 - 1395 WP_042599651.1 sodium-coupled multidrug efflux MATE transporter HmrM -
NTHI477_RS02355 498885..499499 + 615 WP_042599650.1 riboflavin synthase -
NTHI477_RS02360 499571..502180 - 2610 WP_042593851.1 aminopeptidase N -
NTHI477_RS02365 502224..502568 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NTHI477_RS02370 502565..502813 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
NTHI477_RS02375 502984..503478 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
NTHI477_RS02380 503548..504636 + 1089 WP_044330360.1 5-(carboxyamino)imidazole ribonucleotide synthase -
NTHI477_RS02385 504776..505966 + 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
NTHI477_RS02390 506073..506699 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
NTHI477_RS02395 506701..507333 - 633 WP_042594480.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T46486 WP_005653200.1 NZ_CP007470:c502813-502565 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T46486 NZ_CP007470:c502813-502565 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT46486 WP_005653201.1 NZ_CP007470:c502568-502224 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT46486 NZ_CP007470:c502568-502224 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References