Detailed information of TA system TA046483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 1793670..1794202
• Replicon: chromosome
• Accession: NZ_CP007456
• Organism: Bifidobacterium kashiwanohense PV20-2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A0A7I4B7
• Locus tag: AH68_RS07820
• Protein ID: WP_039199122.1
• Coordinates: 1793670..1793933 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: AH68_RS07825
• Protein ID: WP_039199123.1
• Coordinates: 1793933..1794202 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AH68_RS07805	1789417..1789836	-	420	WP_134853612.1	DNA mismatch endonuclease Vsr	-
AH68_RS07810	1790075..1791079	+	1005	WP_052189194.1	Gfo/Idh/MocA family oxidoreductase	-
AH68_RS07815	1791512..1793254	+	1743	WP_144245773.1	UvrD-helicase domain-containing protein	-
AH68_RS07820	1793670..1793933	-	264	WP_039199122.1	Txe/YoeB family addiction module toxin	Toxin
AH68_RS07825	1793933..1794202	-	270	WP_039199123.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AH68_RS10385	1794417..1795820	+	1404	Protein_1529	DUF3427 domain-containing protein	-
AH68_RS10775	1795880..1796029	-	150	WP_158332988.1	hypothetical protein	-
AH68_RS07845	1796300..1797601	+	1302	WP_039199127.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1784380..1795113	10733

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.51 Da
• Isoelectric Point: 7.0093

>T46483 WP_039199122.1 NZ_CP007456:c1793933-1793670 [Bifidobacterium kashiwanohense PV20-2]
VILSWTEDAWDDYLYWQRQDPKTFKRINLLIKDAMRSPAEGIGKPEPLKWALQGAWSRRIDSANRLVYTIDDDGITILSA
KSHYSKE

Nucleotide

• Length: 264 bp

>T46483 NZ_CP007456:c1793933-1793670 [Bifidobacterium kashiwanohense PV20-2]
GTGATTCTCTCGTGGACCGAGGACGCATGGGATGACTATCTGTATTGGCAGAGGCAGGATCCGAAAACCTTCAAACGAAT
CAACTTGCTGATAAAAGATGCCATGCGCTCGCCTGCCGAGGGCATCGGCAAACCCGAACCTCTCAAATGGGCTCTTCAAG
GAGCATGGTCACGTAGAATCGACTCGGCAAACAGGCTCGTCTATACAATCGACGATGACGGCATCACTATTCTCTCCGCC
AAAAGCCACTACAGCAAGGAATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10254.58 Da
• Isoelectric Point: 4.8182

>AT46483 WP_039199123.1 NZ_CP007456:c1794202-1793933 [Bifidobacterium kashiwanohense PV20-2]
MVTAIAYSNFRKELKSYMRKANEDADAILVTNSDPKDNVIVMSASDYDSLMETLHIYENPYLMDKVQRGLAQVKSRQTIR
HDLIEQEGE

Nucleotide

• Length: 270 bp

>AT46483 NZ_CP007456:c1794202-1793933 [Bifidobacterium kashiwanohense PV20-2]
ATGGTTACAGCAATCGCATACAGTAATTTTCGTAAGGAACTTAAGTCCTACATGAGGAAGGCAAACGAGGATGCCGACGC
GATCCTCGTTACGAATTCAGATCCGAAAGACAATGTCATCGTAATGAGCGCTAGTGACTACGACTCCCTTATGGAGACGC
TGCATATCTATGAGAATCCTTACCTTATGGACAAGGTGCAAAGGGGATTGGCTCAAGTTAAGTCAAGGCAGACTATTCGT
CATGACCTGATCGAGCAAGAGGGGGAATAG

Structures

Toxin

• AlphaFold DB: A0A0A7I4B7